Integrin signaling: linking mechanical stimulation to skeletal muscle hypertrophy.

Am J Physiol Cell Physiol

Department of Physical Therapy and Athletic Training, University of Utah, Salt Lake City, Utah.

Published: October 2019

The αβ-integrin is a transmembrane adhesion protein that connects laminin in the extracellular matrix (ECM) with actin in skeletal muscle fibers. The αβ-integrin is highly expressed in skeletal muscle and is concentrated at costameres and myotendious junctions, providing the opportunity to transmit longitudinal and lateral forces across the membrane. Studies have demonstrated that α-integrin subunit mRNA and protein are upregulated following eccentric contractions as a mechanism to reinforce load-bearing structures and resist injury with repeated bouts of exercise. It has been hypothesized for many years that the integrin can also promote protein turnover in a manner that can promote beneficial adaptations with resistance exercise training, including hypertrophy. This review provides basic information about integrin structure and activation and then explores its potential to serve as a critical mechanosensor and activator of muscle protein synthesis and growth. Overall, the hypothesis is proposed that the αβ-integrin can contribute to mechanical-load induced skeletal muscle growth via an mammalian target of rapamycin complex 1-independent mechanism.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6850995PMC
http://dx.doi.org/10.1152/ajpcell.00009.2019DOI Listing

Publication Analysis

Top Keywords

skeletal muscle
16
muscle
5
integrin signaling
4
signaling linking
4
linking mechanical
4
mechanical stimulation
4
skeletal
4
stimulation skeletal
4
muscle hypertrophy
4
hypertrophy αβ-integrin
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!