AI Article Synopsis
- Insulin and insulin resistance (IR) are linked to metabolism and neural health, and both are considered risk factors for Alzheimer's disease (AD) due to their potential effects on white matter myelination.
- A study used neuroimaging techniques to examine the relationship between insulin, IR, and myelin in cognitively unimpaired adults, finding that higher IR was associated with reduced myelin in white matter but increased myelin in gray matter.
- The findings imply that insulin levels and IR may impact white matter myelination, highlighting the need for further research on their role in cognitive decline and neurodegenerative diseases.
Article Abstract
Objective: Insulin regulates metabolism and influences neural health. Insulin resistance (IR) and type II diabetes have been identified as risk factors for Alzheimer disease (AD). Evidence has also suggested that myelinated white matter alterations may be involved in the pathophysiology of AD; however, it is unknown whether insulin or IR affect the underlying myelin microstructure. The relationships between insulin, IR, and myelin were examined, with the hypothesis that IR would be associated with reduced myelin.
Methods: Cognitively unimpaired adults enriched for risk factors for AD underwent multicomponent driven equilibrium single pulse observation of T1 and T2 imaging, a myelin-sensitive neuroimaging technique. Linear regressions were used to test the relationship between homeostatic model assessment of IR, insulin, and myelin water fraction (MWF) as well as interactions with APOE ε4.
Results: Both IR and insulin level were associated with altered myelin content, wherein a significant negative association with MWF was observed in white matter regions and a positive association with MWF was observed in gray matter.
Conclusions: The results suggest that insulin and IR influence white matter myelination in a cognitively unimpaired population. Additional studies are needed to determine the extent to which this may contribute to cognitive decline or vulnerability to neurodegenerative disease.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6707894 | PMC |
| http://dx.doi.org/10.1002/oby.22558 | DOI Listing |
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