Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1111/1346-8138.15017 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
PDPN+ cancer-associated fibroblasts enhance gastric cancer angiogenesis via AKT/NF-κB activation and the CCL2-ACKR1 axis.
MedComm (2020)
January 2025
Department of Oncology Shanghai Medical College, Fudan University Shanghai China.
Cancer-associated fibroblasts (CAFs) are intrinsic components of the tumor microenvironment that promote cancer progression and metastasis. Through an unbiased integrated analysis of gastric tumor grade and stage, we identified a subset of proangiogenic CAFs characterized by high podoplanin (PDPN) expression, which are significantly enriched in metastatic lesions and secrete chemokine (CC-motif) ligand 2 (CCL2). Mechanistically, PDPN(+) CAFs enhance angiogenesis by activating the AKT/NF-κB signaling pathway.
View Article and Find Full Text PDFSurfactant Protein-C Regulates Alveolar Type 2 Epithelial Cell Lineages via the CD74 Receptor.
J Respir Biol Transl Med
December 2024
Department of Surgery, Stritch School of Medicine, Loyola University Chicago, Maywood, IL 60153, USA.
Background: Deficiency of surfactant protein-C (SPC) increases susceptibility to lung infections and injury, and suppressed expression of SPC has been associated with the severity of acute respiratory distress syndrome (ARDS). Alveolar type 2 epithelial cells (AT2) are critical for maintenance and repair of the lung. However, the role of the SPC in the regulation of AT2 cell lineage and the underlying mechanisms are not completely understood.
View Article and Find Full Text PDFEffects of cadherin mediated contact normalization on oncogenic Src kinase mediated gene expression and protein phosphorylation.
Sci Rep
October 2024
Rowan-Virtua School of Osteopathic Medicine, Rowan University, B330 Science Center, 2 Medical Center Dr., Stratford, NJ, 08084, USA.
Nontransformed cells form heterotypic cadherin junctions with adjacent transformed cells to inhibit tumor cell growth and motility. Transformed cells must override this form of growth control, called "contact normalization", to invade and metastasize during cancer progression. Heterocellular cadherin junctions between transformed and nontransformed cells are needed for this process.
View Article and Find Full Text PDFDecorin suppresses tumor lymphangiogenesis: A mechanism to curtail cancer progression.
Proc Natl Acad Sci U S A
April 2024
Department of Pathology and Genomic Medicine, and the Translational Cellular Oncology Program, Sidney Kimmel Cancer Center, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, PA 19107.
Article Synopsis
- Decorin is a special type of protein made by cells in tumors that can stop cancer cells from growing by affecting certain signals in the body.
- Scientists found that when decorin is given to mice with breast cancer, it reduces the development of lymphatic vessels, which help tumors spread.
- The research suggests that decorin could be a new treatment to slow down or stop the growth of breast cancer by blocking these pathways.
Maackia amurensis seed lectin (MASL) and soluble human podoplanin (shPDPN) sequence analysis and effects on human oral squamous cell carcinoma (OSCC) cell migration and viability.
Biochem Biophys Res Commun
May 2024
Molecular Biology, Rowan Virtua SOM, Rowan University, 2 Medical Center Dr., Stratford, NJ, 08084, USA. Electronic address:
Article Synopsis
- Maackia amurensis lectins, specifically M. amurensis seed lectin (MASL), bind to sialic acid residues on proteins, showing potential to reduce inflammation in arthritic cells and inhibit tumor growth and movement.
- The study characterized MASL into two groups based on its ability to form dimers, with MASL having unique isoforms and glycosylation sites that significantly impact its function and interaction with the podoplanin (PDPN) receptor.
- Results indicate that MASL exhibits strong binding to PDPN and can effectively inhibit the growth and motility of oral squamous cell carcinoma (OSCC) cells, highlighting its potential use as an antic
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!