AI Article Synopsis
Article Abstract
Background: Acute promyelocytic leukemia (APL) is characterized by fusion of PML/RARα genes as a result of t(15;17)(q24;q21). APL is now one of the curable hematological malignancies thanks to molecularly targeted therapies based on all-trans retinoic acid (ATRA) and arsenic trioxide (ATX). Extramedullary (EM) relapse is a rare event in APL, ear involvement being even more infrequent, with only six cases so far described. About 30-35% of patients with newly diagnosed APL have additional cytogenetics abnormalities, whose prognostic significance is still controversial. The most common additional aberration is trisomy 8 or partial gain 8q.
Case Presentation: We describe here a novel unbalanced translocation der(3)t(3;8)(q29;q23.3-q24.3) associated with 8q partial gain in a 41 year-old man affected by APL in molecular remission after first line treatment, who had a responsive EM relapse in the auditory canal.
Conclusions: EM relapse is a rare event in APL and ear involvement is even more infrequent. To our knowledge, this is the first reported case of APL with a new der(3)t(3;8)(q29;q23.3-q24.3) and 8q partial gain associated with t(15;17)(q24;q21). Despite the recurrence of the disease at EM level, the clinical outcome of this patients was favorable.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6612227 | PMC |
| http://dx.doi.org/10.1186/s13039-019-0445-1 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Investigating the resilience of kidneys in rats exposed to chronic partial sleep deprivation and circadian rhythm disruption as disruptive interventions.
Neurobiol Sleep Circadian Rhythms
May 2025
Cellular and Molecular Research Center, Department of Anatomical Sciences, Birjand University of Medical Sciences, Birjand, Iran.
Sleep is a vital biological function that significantly influences overall health. While sleep deprivation (SD) and circadian rhythm disruption are known to negatively impact various organs, their specific effects on kidney function remain understudied. This study aimed to investigate the impact of chronic partial sleep deprivation and circadian rhythm disruption on renal function in rats, providing insights into the relationship between sleep disturbances and kidney health.
View Article and Find Full Text PDFMultisystem clinicopathologic and genetic analysis of MELAS.
Orphanet J Rare Dis
December 2024
Department of Pathology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Zhongshan Road 321#, Nanjing, 210008, Jiangsu, China.
Background And Objectives: Mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes (MELAS) syndrome is a maternally inherited mitochondrial disorder that mostly affects the central nervous system and skeletal muscle. This study provides a comprehensive summary of the clinical symptoms, multisystemic pathogenesis, and genetic characteristics of MELAS syndrome. The aim was to improve comprehension of clinical practice and gain a deeper understanding of the latest pathophysiological theories.
View Article and Find Full Text PDFShort-chain fatty acids as a novel intervention for high-fat diet-induced metabolic syndrome.
Mol Cell Biochem
December 2024
Department of Biophysics, Panjab University, Chandigarh, 160014, India.
Metabolic syndrome (MetS) is driven by a complex interplay of genetic, lifestyle, and dietary factors, leading to weight gain, insulin resistance, dyslipidemia, and chronic inflammation. Gut microbiota dysbiosis has been recently recognized as a key contributor to MetS, leading to advancements in gut microbiome-based interventions to improve health outcomes. Considering the unique challenges associated with the use of pre/probiotics, short-chain fatty acids (SCFA), also known as postbiotics, have emerged as promising therapeutic agents due to their role in modulating host metabolism and physiology.
View Article and Find Full Text PDFStructural characterization of polysaccharide isolated from Inonotus hispidus and its anti-obesity effect based on regulation of the interleukin-17-mediated inflammatory response.
Int J Biol Macromol
December 2024
Engineering Research Center of Chinese Ministry of Education for Edible and Medicinal Fungi, Jilin Agricultural University, Changchun, 130118, China; School of Life Sciences, Jilin University, Changchun 130012, China. Electronic address:
A heteropolysaccharide (IHP3) with a molecular weight of 22.0 kDa was isolated from Inonotus hispidus (Bull.: Fr.
View Article and Find Full Text PDFUse of almond hulls in lamb diets - Effects on growth performance and carcass and meat quality.
Meat Sci
December 2024
Centro de Biotecnologia Agrícola e Agro-Alimentar do Alentejo (CEBAL) / Instituto Politécnico de Beja (IPBeja), 7801-908 Beja, Portugal; MED - Mediterranean Institute for Agriculture, Environment and Development & CHANGE - Institute for Global Changes and Sustainability, CEBAL, 7801-908 Beja, Portugal. Electronic address:
The effect of partial replacement of cereals by increasing levels of almond hulls (AH) was tested in twenty-four lambs distributed into three dietary treatments: 1) diet without replacement of cereals with AH (0AH); 2) diet with replacement of cereals with 9% of AH (9AH); and 3) diet with replacement of cereals with 18% of AH (18AH). All diets included 40% dehydrated lucerne and 5% soybean oil. Dry matter intake, growth performance, feed costs, carcass traits, meat quality, and lipid oxidative stability of raw and cooked meat during refrigerated storage were evaluated.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!