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Retrospective Cohort Study of Lassa Fever in Pregnancy, Southern Nigeria. | LitMetric

AI Article Synopsis

  • * The study found that women with a dead fetus had a significantly higher death rate (58.8%) compared to those with a live fetus (7.7%).
  • * Despite the risks, positive outcomes for women with a live fetus suggest that a conservative obstetric management approach may be beneficial in treating Lassa fever during pregnancy.

Article Abstract

Lassa fever in pregnancy causes high rates of maternal and fetal death, but limited data are available to guide clinicians. We retrospectively studied 30 pregnant Lassa fever patients treated with early ribavirin therapy and a conservative obstetric approach at a teaching hospital in southern Nigeria during January 2009–March 2018. Eleven (36.7%) of 30 women died, and 20/31 (64.5%) pregnancies ended in fetal or perinatal loss. On initial evaluation, 17/30 (56.6%) women had a dead fetus; 10/17 (58.8%) of these patients died, compared with 1/13 (7.7%) of women with a live fetus. Extravaginal bleeding, convulsions, and oliguria each were independently associated with maternal and fetal or perinatal death, whereas seeking care in the third trimester was not. For women with a live fetus at initial evaluation, the positive outcomes observed contrast with previous reports, and they support a conservative approach to obstetric management of Lassa fever in pregnancy in Nigeria.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6649346PMC
http://dx.doi.org/10.3201/eid2508.181299DOI Listing

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