Fungi are a rich source of novel anticancer compounds. Bioassay-guided isolation has led to the isolation of four polyketide-amino acid hybrid compounds with -fused decalin system from the fungus ATCC 42464 (= ATCC 42464): myceliothermophins A, B, E and F (-). The structure of the new compound (myceliothermophin F, compound ) was clearly determined by a combination of nuclear magnetic resonance (NMR) analysis and high-resolution electrospray ionisation mass spectroscopy (HRESIMS). The new compound exhibited promising cytotoxicity against some cell lines derived from colorectal carcinoma, hepatic carcinoma and gastric carcinoma, indicating that compounds with -fused decalin system would be promising in the course of developing novel anticancer drugs.
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