AI Article Synopsis
- The outcome of Leishmania infection is influenced by the species of the parasite and the host's immune response, with a focus on understanding virulence factors for vaccine and treatment development.
- Arginase activity is crucial for parasite replication and infectivity, particularly in L. amazonensis, as its absence results in reduced infectivity.
- A reanalysis of transcriptomic data from different strains of L. amazonensis revealed that arginase not only affects the polyamines pathway but also modulates virulence factors related to the parasite’s recognition, growth, and differentiation.
Article Abstract
The outcome of Leishmania infection depends on the parasite species and the host immune response. Virulence factors have been extensively studied over the years in an effort to find efficient vaccines and/or treatments for Leishmania infection. Arginase activity in Leishmania has been described as an essential player for the polyamines pathway, impacting parasite replication and infectivity. Considering previous studies showing that the absence of arginase activity leads to low infectivity of Leishmania amazonensis, we reanalyzed transcriptomic data comparing both promastigotes and axenic amastigotes from L. amazonensis wild type (La-WT) and L. amazonensis arginase knockout (La-arg) backgrounds. The analysis produced a new compilation of modulated transcripts that indicated the role of arginase not only in the polyamines pathway but also in the modulation of virulence factors involved in parasite recognition, growth and differentiation.
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| http://dx.doi.org/10.1016/j.mib.2019.06.003 | DOI Listing |
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