Objective: To assess the survival and complication rates of tooth-implant supported fixed dental prostheses (T-I FDPs).
Sources: An electronic search in MEDLINE/PubMed, Cochrane Library, and Embase was conducted using MeSH terms to identify randomised controlled trials (RCTs) or prospective studies with an observation period of at least 3 years, including at least 10 participants.
Study Selection: Included studies were qualitatively assessed. Survival rates of T-I FDPs and implants as well as technical and biological complications were obtained. Failure and complication rates were pooled by weighting each rate in inverse proportion to its variance.
Data: A total of eight studies were considered for qualitative analysis; seven studies with a minimum follow-up of five years were included for quantitative analysis. Estimated survival rates of T-I FDPs were 90.8% (95% CI: 86.4-93.8%) after five years and 82.5% (95% CI: 74.7-88.0%) after 10 years. Implant survival estimates were 94.8% (90.9-97.0%) and 89.8% (82.7-99.4%) after 5 and 10 years, respectively. From a total of 185 T-I FDPs, 21 (11.4%) minor and 23 (12.4%) major biological complications were observed, whereas 23 (12.4%) minor and three (1.6%) major technical complications occurred.
Conclusions: Due to the lack of well-designed studies exceeding a 10-year follow-up, prognosis for the long -term can hardly be given. Considering the inclusion criteria of this systematic review, T-I FDP-supported fixed dental prostheses show acceptable survival rates after five and 10 years. Rigidly constructed T-I FDPs should be preferred. With regard to the available data, these conclusions are valid only for three- to four-unit T-I FDPs.
Clinical Significance: Tooth-implant supported fixed dental prostheses are a recommendable treatment option in partial dentition. Based on the current literature, they should be rigidly constructed with a maximum number of four units.
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http://dx.doi.org/10.1016/j.jdent.2019.07.005 | DOI Listing |
Int J Surg
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Department of Orthopaedics, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
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Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai, China.
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Biomol Biomed
January 2025
Necmettin Erbakan University, Meram Faculty of Medicine, Department of Medical Oncology, Konya, Turkey.
The cysteine-rich epidermal growth factor ligand domain 2 protein (CRELD2) is associated with pathways that regulate epithelial-to-mesenchymal transition, a critical process driving cancer metastasis. This study aimed to determine the prognostic value of CRELD2 status on survival outcomes in triple-negative breast cancer (TNBC). Seventy patients were included in the study.
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Department of Cardiovascular Surgery, Nanchong Central Hospital, The Affiliated Nanchong Central Hospital of North Sichuan Medical College, Nanchong Hospital of Beijing Anzhen Hospital Capital Medical University, Nanchong, China.
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Methods: A systematic search of the PubMed, Embase, and Cochrane Library databases for relevant studies was performed. Outcome data, including postoperative mortality and morbidity, operative details, all-cause survival, freedom from aortic-related survival and freedom from aortic-related re-intervention, were independently extracted by two authors in a standardized way.
JAMA
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CRIMM, Center Research and Innovation of Myeloproliferative Neoplasms, University of Florence, AOU Careggi, Florence, Italy.
Importance: Essential thrombocythemia, a clonal myeloproliferative neoplasm with excessive platelet production, is associated with an increased risk of thrombosis and bleeding. The annual incidence rate of essential thrombocythemia in the US is 1.5/100 000 persons.
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