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Tuberous sclerosis complex mutations in patients with pancreatic neuroendocrine tumors. Observations on phenotypic and treatment-related associations.
Virchows Arch
August 2023
Department of Medicine, Division of Oncology, Washington University Medical School, St. Louis, MO, USA.
Pancreatic neuroendocrine tumors (PanNETs) in familial tuberous sclerosis (TSC1 and TSC2 mutations) have been known and studied. However, little is known about PanNET patients harboring the very rare (less than 2%) sporadic TSC mutations. Some renal tumors have been shown to harbor sporadic TSC mutations, with a distinctive morphological correlate.
View Article and Find Full Text PDFThe 2022 revision of the World Health Organization classification of tumors of the urinary system and male genital organs: advances and challenges.
Hum Pathol
June 2023
Department of Pathology and Laboratory Medicine, Warren Alpert Medical School of Brown University, Lifespan Academic Medical Center, Providence, RI, 02903, USA. Electronic address:
The fifth edition of the World Health Organization (WHO) classification of urinary and male genital organ tumors has been recently published in 2022. The application of molecular profiling has made a substantial impact on the classification of urologic tumors. The new WHO classification introduces a group of molecularly well-defined renal tumor subtypes.
View Article and Find Full Text PDFDoes 68Ga-DOTA-NOC-PET/CT impact staging and therapeutic decision making in pulmonary carcinoid tumors?
Nucl Med Commun
October 2020
Department of Nuclear Medicine and Molecular Imaging.
Objective: Purpose of this study was to assess the utility of Ga-DOTA-NOC-PET/computed tomography (CT) (Ga-NOC-PET) in tumor detection, pathological differentiation and baseline staging of pulmonary carcinoids as well as to study its impact on therapeutic decision making.
Patients And Methods: Patients who underwent a Ga-NOC-PET for initial evaluation of bronchopulmonary carcinoid tumors from August 2014 to December 2019 were included. Detection rate of Ga-NOC-PET for the primary lesion was calculated by visual estimation of tracer uptake as per Krenning score.
Oncocytic carcinoid tumor of the lung complicated by tuberculosis.
Chin Med J (Engl)
August 2019
Department of Cardiology, The First Norman Bethune Hospital of Jilin University, Changchun, Jilin 130021, China.
Surgical outcomes in 13 patients with bronchopulmonary carcinoid tumors including one recurrent oncocytic carcinoid tumor.
Gen Thorac Cardiovasc Surg
May 2019
Department of Pathology, National Hospital Organization, Shikoku Cancer Center, Matsuyama, Japan.
Introduction: Bronchopulmonary carcinoids are low-grade tumors for which the standard treatment is surgical resection. We retrospectively evaluated the surgical outcomes.
Methods: Thirteen patients underwent surgical resection for them at our institution between January 2005 and December 2016.
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