Meloxicam (MX), a nonsteroidal anti-inflammatory drug, widely used to treat arthritis, has a very bitter taste. Chemical modification of the bitter functionality was achieved by synthesis of a prodrug, meloxicam pivalate (MXP). Taste improvement was evaluated using single bottle-test rat model. It was found that palatability of MXP solution improved significantly as compared to MX.
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| http://dx.doi.org/10.1080/03639045.2019.1628250 | DOI Listing |
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Synthesis and taste assessment of meloxicam pivalate.
Drug Dev Ind Pharm
October 2019
Department of Pharmaceutical Sciences & Technology, Institute of Chemical Technology, Mumbai , India.
Meloxicam (MX), a nonsteroidal anti-inflammatory drug, widely used to treat arthritis, has a very bitter taste. Chemical modification of the bitter functionality was achieved by synthesis of a prodrug, meloxicam pivalate (MXP). Taste improvement was evaluated using single bottle-test rat model.
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