AI Article Synopsis
- AIEgens are unique materials with special optical properties and design flexibility that have gained a foothold in smart material applications since their discovery in 2001.
- Recent research highlights their use in biomedical fields for sensing, imaging, and therapy, particularly focusing on their anticancer properties.
- The study reveals AIEgens' strong cytotoxic effects against cancer cells and especially cancer stem cells, suggesting their potential as innovative image-guided chemotherapy agents for more effective cancer treatments.
Article Abstract
Fluorogens with aggregation-induced emission (AIE) characteristics (AIEgens) possess unique optical properties, design flexibility, and multi-functional capabilities and have established their niche as smart materials since their discovery in 2001. In recent years, AIEgens have found varied applications in sensing, imaging, and therapy in biomedical research. In this work, we systematically and comprehensively investigate the in vitro anticancer activity of AIEgens. We report the high cytotoxicity of AIEgens against cancer cells, especially against cancer stem cells (CSCs) which show high resistance to existing therapeutic drug regimens. Furthermore, we explore the role of AIEgens as novel image-guided chemotherapy agents that offer a new avenue for efficient cancer treatment.
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| http://dx.doi.org/10.1039/c9bm00881k | DOI Listing |
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