-Terphenyls and actinomycins from a sp. associated with the larva of mud dauber wasp.

In the course of searching for cytotoxic metabolites from insects associated actinomyces, two new natural -terphenyl glycosides, strepantibin D () and strepantibin E (), along with terferol (), actinomycin D (), actinomycin V () and actinomycin V (), were identified from the fermentation medium of a sp. which was obtained from the larva body of mud dauber wasp. Strepantibin D (), previously reported as a synthetic derivative of terfestatin A, is firstly isolated as a natural -terphenyl in this research. Strepantibin D () and terferol () showed medium cytotoxic activity against breast cancer cells MCF-7, MDA-MB-231 and BT-474. Actinomycins (-), especially actinomycin V (), displayed remarkable cytotoxicity against breast cancer cells, with IC values ranging from 0.83 nM to 369.90 nM.