The academic and behavioral progress of children is associated with the timely development of reading and writing skills. Dysgraphia, characterized as a handwriting learning disability, is usually associated with dyslexia, developmental coordination disorder (dyspraxia), or attention deficit disorder, which are all neuro-developmental disorders. Dysgraphia can seriously impair children in their everyday life and require therapeutic care. Early detection of handwriting difficulties is, therefore, of great importance in pediatrics. Since the beginning of the 20th century, numerous handwriting scales have been developed to assess the quality of handwriting. However, these tests usually involve an expert investigating visually sentences written by a subject on paper, and, therefore, they are subjective, expensive, and scale poorly. Moreover, they ignore potentially important characteristics of motor control such as writing dynamics, pen pressure, or pen tilt. However, with the increasing availability of digital tablets, features to measure these ignored characteristics are now potentially available at scale and very low cost. In this work, we developed a diagnostic tool requiring only a commodity tablet. To this end, we modeled data of 298 children, including 56 with dysgraphia. Children performed the BHK test on a digital tablet covered with a sheet of paper. We extracted 53 handwriting features describing various aspects of handwriting, and used the Random Forest classifier to diagnose dysgraphia. Our method achieved 96.6% sensibility and 99.2% specificity. Given the intra-rater and inter-rater levels of agreement in the BHK test, our technique has comparable accuracy for experts and can be deployed directly as a diagnostics tool.
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http://dx.doi.org/10.1038/s41746-018-0049-x | DOI Listing |
Parkinsonism Relat Disord
December 2024
The Nash Family Center for Advanced Circuit Therapeutics at the Icahn School of Medicine at Mount Sinai West, New York, NY, 10019, United States.
Introduction: Subthalamic nucleus deep brain stimulation (STN DBS) improves motor symptoms of Parkinson's disease (PD), but its effect on motivation is controversial. Apathy, the lack of motivation, commonly occurs in PD and is often exacerbated after surgery and its concomitant levodopa reduction. Apathy and reward processing are associated with the ventromedial prefrontal cortex (vmPFC), which standard targeting strategies avoid by targeting the dorsolateral STN.
View Article and Find Full Text PDFAm J Geriatr Psychiatry
December 2024
Department of Neurology (HL, BHK, EHL, DS, HY, SWS, JPK), Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea; Alzheimer's Disease Convergence Research Center (HL, BHK, EHL, DS, HY, SWS, JPK), Samsung Medical Center, Seoul, Republic of Korea; Neuroscience Center (EHL, DS, SWS, JPK), Samsung Medical Center, Seoul, Republic of Korea. Electronic address:
Objective: Brain atrophy measured by structural imaging has been used to quantify resilience against neurodegeneration in Alzheimer's disease. Considering glucose hypometabolism is another marker of neurodegeneration, we quantified metabolic resilience (MR) based on Fluorodeoxyglucose positron emission tomography (FDG PET) and investigated its clinical implications.
Methods: We quantified the MR and other resilience metrics, including brain resilience (BR) and cognitive resilience (CR), using partial least squares path modeling from the ADNI database.
Radiol Artif Intell
July 2024
From the Artificial Intelligence in Medicine (AIM) Program, Mass General Brigham, Harvard Medical School, Boston, Mass (A.B., Z.Y., Y.Z., A.Z., H.H., R.C., H.J.W.L.A., B.H.K.); Department of Radiation Oncology (A.B., Z.Y., M.C.T., Y.Z., A.Z., H.H., R.C., K.X.L., D.A.H.K., H.J.W.L.A., B.H.K.) and Department of Radiology (H.J.W.L.A.), Brigham and Women's Hospital, Dana-Farber Cancer Institute, Harvard Medical School, 75 Francis St, Boston, MA 02115; Department of Radiology, Boston Children's Hospital, Harvard Medical School, Boston, Mass (S.P.P., S.V., T.Y.P.); Department of Biostatistics and Computational Biology, Harvard T.H. Chan School of Public Health, Boston, Mass (P.J.C.); Center for Data-Driven Discovery in Biomedicine (D3b) (A.N., A.C.R.) and Department of Neurosurgery (A.C.R.), Children's Hospital of Philadelphia, Philadelphia, Pa; Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pa (A.N.); Departments of Neurology, Pediatrics, and Neurologic Surgery, University of California, San Francisco, San Francisco, Calif (S.M.); and Department of Radiology and Nuclear Medicine, CARIM & GROW, Maastricht University, Maastricht, the Netherlands (H.J.W.L.A.).
Purpose To develop, externally test, and evaluate clinical acceptability of a deep learning pediatric brain tumor segmentation model using stepwise transfer learning. Materials and Methods In this retrospective study, the authors leveraged two T2-weighted MRI datasets (May 2001 through December 2015) from a national brain tumor consortium ( = 184; median age, 7 years [range, 1-23 years]; 94 male patients) and a pediatric cancer center ( = 100; median age, 8 years [range, 1-19 years]; 47 male patients) to develop and evaluate deep learning neural networks for pediatric low-grade glioma segmentation using a stepwise transfer learning approach to maximize performance in a limited data scenario. The best model was externally tested on an independent test set and subjected to randomized blinded evaluation by three clinicians, wherein they assessed clinical acceptability of expert- and artificial intelligence (AI)-generated segmentations via 10-point Likert scales and Turing tests.
View Article and Find Full Text PDFRadiol Artif Intell
May 2024
From the Artificial Intelligence in Medicine Program, Mass General Brigham, Harvard Medical School, Boston, Mass (D.T., Z.Y., A.Z., Y.Z., A.B., R.C., H.H., H.J.W.L.A., B.H.K.); Department of Radiation Oncology, Dana-Farber Cancer Institute, Brigham and Women's Hospital, Boston Children's Hospital, Harvard Medical School, 75 Francis St, Boston, MA 02115 (D.T., Z.Y., A.Z., Y.Z., A.B., R.C., H.H., K.X.L., H.E., H.J.W.L.A., D.A.H.K., B.H.K.); Department of Radiology, Boston Children's Hospital, Harvard Medical School, Boston, Mass (S.V., S.P.P., T.Y.P.); Center for Data-Driven Discovery in Biomedicine (A.N., A.F.) and Department of Neurosurgery (A.F., A.C.R.), Children's Hospital of Philadelphia, Philadelphia, Pa; Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pa (A.N.); Departments of Neurology, Pediatrics, and Neurologic Surgery, University of California San Francisco, San Francisco, Calif (S.M.); Department of Radiology, Brigham and Women's Hospital, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Mass (H.J.W.L.A.); Department of Radiology and Nuclear Medicine, CalifRIM & GROW, Maastricht University, Maastricht, the Netherlands (H.J.W.L.A.); and Department of Pediatric Oncology (P.B.) and Department of Pathology (K.L.L.), Dana-Farber Cancer Institute, Boston Children's Hospital, Harvard Medical School, Boston, Mass.
Purpose To develop and externally test a scan-to-prediction deep learning pipeline for noninvasive, MRI-based mutational status classification for pediatric low-grade glioma. Materials and Methods This retrospective study included two pediatric low-grade glioma datasets with linked genomic and diagnostic T2-weighted MRI data of patients: Dana-Farber/Boston Children's Hospital (development dataset, = 214 [113 (52.8%) male; 104 (48.
View Article and Find Full Text PDFBraz J Microbiol
June 2024
Faculty of Science, Universidad Antonio Nariño (UAN), Sede Circunvalar. Cra. 3 Este # 47A - 15, 110231, Bogotá, Colombia.
Chikungunya (CHIKV), Zika (ZIKV), and dengue viruses (DENV) are vector-borne pathogens that cause emerging and re-emerging epidemics throughout tropical and subtropical countries. The symptomatology is similar among these viruses and frequently co-circulates in the same areas, making the diagnosis arduous. Although there are different methods for detecting and quantifying pathogens, real-time reverse transcription-polymerase chain reaction (real-time RT-qPCR) has become a leading technique for detecting viruses.
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