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| http://dx.doi.org/10.1038/s41538-018-0025-5 | DOI Listing |
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Patient and public involvement in the design and protocol development for a platform randomised trial to evaluate diagnostic tests to optimise antimicrobial therapy (PROTECT).
NIHR Open Res
September 2024
Centre for Trials Research, Cardiff University, Cardiff, Wales, CF14 4YS, UK.
Background: Our patient and public involvement activities were part of a project aiming to develop a master protocol and National Institute for Health and Care research application for the PROTECT trial aiming to assess the effectiveness, implementation, and efficiency of antimicrobial stewardship interventions, to safely reduce unnecessary antibiotic usage by excluding severe bacterial infection in acutely unwell patients.
Methods: Three public involvement sessions were held with representation from young people and parents, people from diverse backgrounds and people with experience of presenting to the emergency department with undifferentiated illness. The teleconference meetings lasted between 60-90 minutes, were recorded, notes were subsequently taken, and findings summarised.
An Exploratory Study of PN HPT for Treating Postsurgical Atrophic and Depressed Scars.
J Cosmet Dermatol
January 2025
Clinical Pharmacology Consultant in Aesthetic Medicine, Milan, Italy.
Background: Postsurgical atrophic scars tend to respond poorly to treatments, especially non-energy-based ones. Hydrophilic PN HPT (Polynucleotides High Purification Technology) injected intradermally is a non-energy-based option with an immediate volume-enhancing effect that indirectly improves the fibroblast synthesis of collagen and extracellular matrix. The PN HPT ingredient has the further benefit of a dermal "priming" effect that enhances the efficacy of other scar treatments.
View Article and Find Full Text PDFAdvanced Monocular Outdoor Pose Estimation in Autonomous Systems: Leveraging Optical Flow, Depth Estimation, and Semantic Segmentation with Dynamic Object Removal.
Sensors (Basel)
December 2024
Electrical, Computer, and Biomedical Engineering, Toronto Metropolitan University, Toronto, ON M5B 2K3, Canada.
Autonomous technologies have revolutionized transportation, military operations, and space exploration, necessitating precise localization in environments where traditional GPS-based systems are unreliable or unavailable. While widespread for outdoor localization, GPS systems face limitations in obstructed environments such as dense urban areas, forests, and indoor spaces. Moreover, GPS reliance introduces vulnerabilities to signal disruptions, which can lead to significant operational failures.
View Article and Find Full Text PDFMinimally invasive surgery for evacuation of intracerebral hematoma by neurointerventionalists: initial experience.
J Neurointerv Surg
January 2025
Neuroscience, Valley Baptist Medical Center - Harlingen, Harlingen, Texas, USA.
Background: There is growing interest and evidence in spontaneous intracerebral hemorrhage (ICH) evacuation with minimally invasive surgery (MIS). If early ICH evacuation becomes the standard of care, training neurointerventionalists to perform MIS would expand global access to treatment. We present a retrospective analysis of patients who underwent MIS-ICH evacuation performed by interventional neurologists in collaboration with neurosurgeons.
View Article and Find Full Text PDFAdherence to institutional stroke alert criteria in an academic adult emergency department population.
Clin Neurol Neurosurg
December 2024
Department of Emergency Medicine, Vanderbilt University Medical Center, Nashville, TN, USA; Geriatric Research, Education, and Clinical Center, Tennessee Valley Healthcare Center, Nashville, TN, USA; Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA. Electronic address:
Background: Timely recognition of acute ischemic stroke (AIS) is essential to identify patients who may be eligible for acute intervention. Protocols to streamline systems-based care, such as "stroke alerts" in the emergency department (ED) can safely reduce time-to-care while enhancing safety. However, clinician adherence to stroke alert criteria is poorly described.
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