AI Article Synopsis
- - The article explores the anti-ulcer properties of synthesized metal heterochelates, specifically focusing on their ability to inhibit urease enzymes in vitro.
- - Key ligands used for synthesizing these complexes include 8-hydroxyquinoline and DL-methionine, with various metal ions like Cr (III), Mn (II), and Cu (II) being tested.
- - Results showed that the Cu (II) complex had significant urease inhibition activity (22.6 ± 0.72 μM), comparable to the standard thiourea (21.6 ± 0.12 μM), and docking studies further confirmed the effectiveness of these complexes.
Article Abstract
The current article discusses the activities of several synthesized metal heterochelates in in-vitro as anti-ulcer agents followed by their docking study. For this purpose, two important ligands like 8-hydroxyquinoline and DL-methionine were used in synthesis of heterochelates of metal including Cr (III), Mn (II), Fe (III), Co (II), Ni (II), Cu (II), Zn (II), Cd (II) and Pb (II). It was observed that these complexes showed excellent urease inhibition activities in which thiourea was the standard having IC value 21.6 ± 0.12μM. The Cu (II) complex showed potent inhibitory activity (22.6 ± 0.72 μM) when compared with the standard thiourea (21.6±0.12μM) among the nine synthesized complexes while Mn (II), Fe (III), Cd (II) and Pb (II) also showed better inhibitory activities. The urease inhibitory activities of hetercochelates also tested and validated by docking analysis.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
New Inhibitors of β-1,4-Galactosyltransferase I Discovered by Virtual Screening.
ChemMedChem
December 2024
University of Ljubljana, Faculty of Pharmacy, Askerceva cesta 7, 1000, Ljubljana, SLOVENIA.
Seven different enzymes comprise the galactosyltransferases family, of which β-1,4-galactosyltransferase I (β-1,4-GALT1) is the major contributor to galactosylation activity in cells. Since abnormalities in galactosylation are associated with many pathophysiological conditions, β-1,4-GALT1 is an interesting new target for drug discovery and molecular probe design. There are several known β-1,4-GALT1 inhibitors, but most of them suffer from low cell permeability and thus low in vivo activity.
View Article and Find Full Text PDFDiscrete Synaptic Events Induce Global Oscillations in Balanced Neural Networks.
Phys Rev Lett
December 2024
Laboratoire de Physique Théorique et Modélisation, CY Cergy Paris Université, CNRS, UMR 8089, 95302 Cergy-Pontoise cedex, France.
Despite the fact that neural dynamics is triggered by discrete synaptic events, the neural response is usually obtained within the diffusion approximation representing the synaptic inputs as Gaussian noise. We derive a mean-field formalism encompassing synaptic shot noise for sparse balanced neural networks. For low (high) excitatory drive (inhibitory feedback) global oscillations emerge via continuous or hysteretic transitions, correctly predicted by our approach, but not from the diffusion approximation.
View Article and Find Full Text PDFChemical profiling by HPLC-DAD and GC-MS analysis and antimicrobial potential of Achillea santolina plant extracts against ESBL- producing E. coli and fungal pathogens.
Chem Biodivers
December 2024
M'sila University, Department of Natural and Life Sciences, Road Bordj Bou Arreiridj, M'sila 28000 Algeria, M'sila, ALGERIA.
The study examines the chemical composition and antimicrobial properties of petroleum ether and hydro-methanolic extracts of Achillea santolina(A. santolina) from Algeria. Chemical profiling was performed using High-Performance Liquid Chromatography with Diode Array Detection (HPLC-DAD) for the hydro-methanolic extract and Gas Chromatography-Mass Spectrometry (GC-MS) for the petroleum ether extract.
View Article and Find Full Text PDFEssential Oil from Tetrapanax papyrifer (Hook.) K. Koch: Chemical Composition, Antioxidant Activity, α-Glucosidase Inhibitory Effect Integrating Molecular Docking Analysis.
Chem Biodivers
December 2024
Shandong University, Marine college, Wenhuaxi road 180, 264209, Weihai, CHINA.
The present study investigated the chemical composition of essential oil from Tetrapanax papyrifer and evaluated its antioxidant and anti-α-glucosidase activity. Sixty-one essential oil compounds from Tetrapanax papyrifer were identified by gas chromatography-mass spectrometry (GC-MS) and gas chromatography-flame ionization detector (GC-FID). The essential oil is rich in sesquiterpenoids (96.
View Article and Find Full Text PDFADME, Toxicity, Molecular Docking, Molecular Dynamics, Glucokinase activation, DPP-IV, α-amylase, and α-glucosidase Inhibition Assays of Mangiferin and Friedelin for Antidiabetic Potential.
Chem Biodivers
December 2024
Daffodil International University, Pharmacy, Dhaka 1207, 1207, Dhaka, BANGLADESH.
The study investigates the inhibitory properties of Mangiferin and Friedelin against glucokinase, DPP-IV, α-amylase, and α-glucosidase using computational methods, in vitro enzyme assays, and in-depth ADMET analysis. The study utilized a computer-aided drug design approach to assess the potential therapeutic properties of Mangiferin and Friedelin as T2DM therapeutic agents. Molecular docking studies' outcomes encouraged the evaluation of both compounds in in vitro enzymatic assays.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!