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Clinical Decision Support Using Speech Signal Analysis: Systematic Scoping Review of Neurological Disorders.
J Med Internet Res
January 2025
Knight Foundation of Computing & Information Sciences, Florida International University, Miami, FL, United States.
Background: Digital biomarkers are increasingly used in clinical decision support for various health conditions. Speech features as digital biomarkers can offer insights into underlying physiological processes due to the complexity of speech production. This process involves respiration, phonation, articulation, and resonance, all of which rely on specific motor systems for the preparation and execution of speech.
View Article and Find Full Text PDFEmerging Trends in Neuroblastoma Diagnosis, Therapeutics, and Research.
Mol Neurobiol
January 2025
Translational Oncology Laboratory, Department of Zoology, Hansraj College, Delhi University, New Delhi, 110007, India.
This review explores the current understanding and recent advancements in neuroblastoma, one of the most common extracranial solid pediatric cancers, accounting for ~ 15% of childhood cancer-related mortality. The hallmarks of NBL, including angiogenesis, metastasis, apoptosis resistance, cell cycle dysregulation, drug resistance, and responses to hypoxia and ROS, underscore its complex biology. The tumor microenvironment's significance in disease progression is acknowledged in this study, along with the pivotal role of cancer stem cells in sustaining tumor growth and heterogeneity.
View Article and Find Full Text PDFFactors influencing spatiotemporal variability of NO concentration in urban area: a GIS and remote sensing-based approach.
Environ Monit Assess
January 2025
Air Quality, Climate Change and Health (ACH) Lab, Department of Public Health and Informatics, Jahangirnagar University, 1342, Savar, Dhaka, Bangladesh.
The growing global attention on urban air quality underscores the need to understand the spatiotemporal dynamics of nitrogen dioxide (NO) and its environmental and anthropogenic factors, particularly in cities like Dhaka (Gazipur), Bangladesh, which suffers from some of the world's worst air quality. This study analysed NO concentrations in Gazipur from 2019 to 2022 using Sentinel-5P TROPOMI data on the Google Earth Engine (GEE) platform. Correlations and regression analysis were done between NO levels and various environmental factors, including land surface temperature (LST), normalized difference vegetation index (NDVI), land use and land cover (LULC), population density, road density, settlement density, and industry density.
View Article and Find Full Text PDFAutophagy-targeted Pt(IV) agents: a new horizon in antitumor drug development.
Dalton Trans
January 2025
Institute of Biopharmaceutical Research, Liaocheng University, Liaocheng 252059, P. R. China.
Pt(IV) complexes as prodrugs of Pt(II) drugs exhibit numerous advantages such as enhanced stability, reduced toxicity, increased oral bioavailability, and efficacy in overcoming the drug resistance of Pt(II) compounds, which underscore their significant potential in the advancement of novel Pt anticancer agents. Furthermore, protective autophagy is pivotal in sustaining tumor cell homeostasis and modulating the tumor microenvironment (TME), thereby representing a critical target for the development of antitumor drugs. Specific inhibition or activation of autophagy during chemotherapy would break the internal homeostasis in the TME and increase antitumor activities.
View Article and Find Full Text PDFIonogel-Based Electrodes for Non-Flammable High-Temperature Operating Electrochemical Double Layer Capacitors.
ChemSusChem
January 2025
Bedimensional Spa, Lungotorrente Secca, 3d, 16163, Genova, ITALY.
The design of interfaces between nanostructured electrodes and advanced electrolytes is critical for realizing advanced electrochemical double-layer capacitors (EDLCs) that combine high charge-storage capacity, high-rate capability, and enhanced safety. Toward this goal, this work presents a novel and sustainable approach for fabricating ionogel-based electrodes using a renewed slurry casting method, in which the solvent is replaced by the ionic liquid (IL), namely 1-ethyl-3-methylimidazolium bis(fluorosulfonyl)imide (EMIFSI). This method avoids time-consuming and costly electrolyte-filling steps by integrating the IL directly into the electrode during slurry preparation, while improving the rate capability of EDLCs based on non-flammable ILs.
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