A series of usnic acid benzylidene derivatives (groups ) were designed, synthesized and evaluated for their anticancer activity in the search for potentially new anticancer agents. Compounds , , , and exhibited the most potent cytotoxcity against K562 cell line with IC values of 10.0 ± 3.6, 5.6 ± 0.4, 8.8 ± 1.0, 4.5 ± 0.1 and 8.4 ± 0.4 μM, respectively. It is noteworthy that compound displayed potent cytotoxicity against K562 cells without any cytotoxic effect on HEK293 normal cell line.
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| http://dx.doi.org/10.1080/14786419.2019.1639176 | DOI Listing |
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