Epigenetic regulation is critical for the precise control of cellular fate and developmental programs. Disruption of epigenetic information is increasingly appreciated as a potential driving mechanism in both developmental disorders as well as ubiquitous diseases such as cancer. Consistent with this, mutations in histone modifying enzymes are amongst the most frequent events in all of human cancer. While early studies have focused on the canonical enzymatic functions involved in catalyzing modifications to histones, more recent studies have uncovered a new layer of critical nonenzymatic roles in transcriptional regulation for these proteins. Here, we provide an overview of these surprising, yet exciting, noncanonical, noncatalytic roles, and highlight how these revelations may have important implications for understanding disease and the future of epigenome-targeting therapies.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6697606 | PMC |
| http://dx.doi.org/10.1016/j.tig.2019.06.004 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Mapping the Protein Phosphatase 1 Interactome in Human Cytomegalovirus Infection.
Viruses
December 2024
Division of Infectious Diseases and Tropical Medicine, Department of Medicine I, Medical University of Vienna, 1090 Vienna, Austria.
Protein phosphorylation is a crucial regulatory mechanism in cellular homeostasis. The human cytomegalovirus (HCMV) incorporates protein phosphatase 1 (PP1) into its tegument, yet the biological relevance and mechanisms of this incorporation remain unclear. Our study offers the first characterization of the PP1 interactome during HCMV infection and its alterations.
View Article and Find Full Text PDFDistinct pathways utilized by METTL3 to regulate antiviral innate immune response.
iScience
November 2024
Center for Emerging Infectious Diseases, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, Hubei 430071, China.
Article Synopsis
- METTL3 is a key enzyme that adds m6A modifications to RNA, impacting innate immunity and viral responses.
- Infection with EV71 increases METTL3 levels in both IFN-deficient and proficient cells through changes in transcription and protein modifications.
- METTL3 regulates antiviral responses through both m6A-dependent and independent mechanisms, suggesting it could be a valuable target for developing antiviral treatments.
Characterization of VldE (Spr1875), a Pneumococcal Two-State l,d-Endopeptidase with a Four-Zinc Cluster in the Active Site.
ACS Catal
December 2024
Department of Crystallography and Structural Biology, Consejo Superior de Investigaciones Científicas, Instituto de Química-Física "Blas Cabrera", Madrid 28006, Spain.
Remodeling of the pneumococcal cell wall, carried out by peptidoglycan (PG) hydrolases, is imperative for maintaining bacterial cell shape and ensuring survival, particularly during cell division or stress response. The protein Spr1875 plays a role in stress response, both regulated by the VicRK two-component system (analogous to the WalRK TCS found in Firmicutes). Modular Spr1875 presents a putative cell-wall binding module at the N-terminus and a catalytic C-terminal module (Spr1875) connected by a long linker.
View Article and Find Full Text PDFAdvances in the study of the role of high-frequency mutant subunits of the SWI/SNF complex in tumors.
Front Oncol
December 2024
Chongqing Health Center for Women and Children, Women and Children's Hospital of Chongqing Medical University, Chongqing, China.
SWI/SNF (Switch/Sucrose non-fermentable, switch/sucrose non-fermentable) chromatin remodeling complex is a macromolecular complex composed of multiple subunits. It can use the energy generated by the hydrolysis of ATP (Adenosine triphosphate) to destroy the connection between DNA and histones, achieve the breakdown of nucleosomes, and regulate gene expression. SWI/SNF complex is essential for cell proliferation and differentiation, and the abnormal function of its subunits is closely related to tumorigenesis.
View Article and Find Full Text PDFFungal β-1, 3-glucanosyltransferases: A comprehensive review on classification, catalytic mechanism and functional role.
Int J Biol Macromol
December 2024
School of Food and Biological Engineering, Jiangsu University, Zhenjiang 212013, PR China; Jiangxi Provincial Engineering and Technology Center for Food Additives Bio-production, Dexing 334221, PR China. Electronic address:
β-1,3-Glucans form the major carbohydrate component of fungal cell walls, playing a vital role in cell viability, stress response, virulence, and even healthy functions such as immuno-enhancement. The elongation and branching of β-1,3-glucans is a mystery. More evidence proved the β-1, 3-glucantransferases belonging to GH72 or GH17 family to branch and remodel the synthesized linear β-1, 3-glucan chain by cleaving its internal β-1, 3-linkage and transfer the cleaved fragment to the nonreducing end of another β-1, 3-glucan acceptor.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!