In an attempt to define feasible means to improve compliance with current recommendations on resistance training in older subjects, published evidence on the efficacy and safety of minimally supervised home-based resistance training (MSHBRT) on muscle strength and functionality was systematically evaluated in this population segment for the first time. We performed a meta-analysis using the following data sources: MEDLINE (Ovid), EMBASE and Cochrane, with a total of 1160 subjects with a mean age of 72 ± 6.3 years. MSHBRT modestly increased lower body strength (MD 0.6 Kg, 95% CI, 0.16-1.04) in a diverse population of older adults including subjects with significant age-related diseases. Although earlier evidence indicates that larger increments in muscle performance and function can be attained through more intense and directly supervised resistance training, MSHBRT may comprise a useful and inexpensive method to preserve and even enhance lower body muscle strength in older adults.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.archger.2019.103909 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Suppressing Tymovirus replication in plants using a variant of ubiquitin.
PLoS Pathog
January 2025
Department of Microbiology, Faculty of Science, University of Manitoba, Winnipeg, Manitoba, Canada.
RNA viruses have evolved numerous strategies to overcome host resistance and immunity, including the use of multifunctional proteases that not only cleave viral polyproteins during virus replication but also deubiquitinate cellular proteins to suppress ubiquitin (Ub)-mediated antiviral mechanisms. Here, we report an approach to attenuate the infection of Arabidopsis thaliana by Turnip Yellow Mosaic Virus (TYMV) by suppressing the polyprotein cleavage and deubiquitination activities of the TYMV protease (PRO). Performing selections using a library of phage-displayed Ub variants (UbVs) for binding to recombinant PRO yielded several UbVs that bound the viral protease with nanomolar affinities and blocked its function.
View Article and Find Full Text PDFTo describe the subsets of malignant epithelial cells in gastric cancer, their developmental trajectories and drug resistance characteristics.
Discov Oncol
January 2025
West China School of Medicine, Sichuan University, Chengdu, China.
Gastric cancer is an aggressive malignancy characterized by significant clinical heterogeneity arising from complex genetic and environmental interactions. This study employed single-cell RNA sequencing, using the 10 × Genomics platform, to analyze 262,532 cells from gastric cancer samples, identifying 32 distinct clusters and 10 major cell types, including immune cells (e.g.
View Article and Find Full Text PDFDoes increasing the resistance-training volume lead to greater gains? The effects of weekly set progressions on muscular adaptations in females.
J Sports Sci
January 2025
Metabolism, Nutrition and Strength Training Research Group (GPMENUTF), Department of Physical Education - Federal University of Paraná (UFPR), Curitiba, PR, Brazil.
We investigated the effect of increasing the number of sets per week every fortnight versus performing a constant set volume on muscular adaptations over 12 weeks. Thirty females (RT experience 2.1 ± 1.
View Article and Find Full Text PDF"No Matter the Age or Medical Complexity, People Benefit From That Intensity of Exercise": A Mixed-Methods Study Describing Rehabilitation Provider Perceptions of High-Intensity Resistance Training Among Veterans Receiving Post-Acute Care.
J Geriatr Phys Ther
January 2025
VA Eastern Colorado Geriatric Research Education and Clinical Center (GRECC), VA Eastern Colorado Health Care System, Aurora, Colorado.
Background: In skilled nursing facilities (SNFs), i-STRONGER is a novel, high-intensity resistance training approach that incorporates progressive resistance training to promote greater improvements in patient function compared to usual care. To inform large-scale expansion of i-STRONGER as standard-of-care in SNFs, this mixed-methods study assessed rehabilitation providers' perceptions of i-STRONGER and purported needs for its adoption.
Methods: Forty-three rehabilitation providers participated in an 18-week, interactive i-STRONGER training program.
Investigating the Impact of B Cell-Related Genes on Colorectal Cancer Immunosuppressive Environment and Immunotherapy Evasion.
Drug Dev Res
February 2025
Department of Radiation Oncology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou, Fujian, China.
We aimed to elucidate the prognostic and immunological roles of B cell-related genes in colorectal cancer (CRC). This study comprehensively integrated data from single-cell RNA-sequencing, TCGA, GEO, IMvigor210, GDSC, CancerSEA, HPA, and TISIDB databases to explore prognostic implications and immunological significance of B cell-related gene signature in CRC. We identified seven prognostically significant B cell-related genes for constructing a risk score.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!