The antimicrobial activities of josamycin, erythromycin, and spiramycin against Rickettsia conorii and R. rickettsii were evaluated in two tests: a dye-uptake assay and a plaque assay. The MIC of josamycin was 1 microgram/ml for both species; the MICs of erythromycin and spiramycin were 4 to 8 and 16 to 32 micrograms/ml, respectively, for both species. Only josamycin may be of clinical use in treating spotted fever rickettsiosis. It may be useful in treating pregnant women and young children.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC172145 | PMC |
| http://dx.doi.org/10.1128/AAC.32.2.255 | DOI Listing |
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