AI Article Synopsis
- This study aimed to assess the incidence and types of cancers in patients with rheumatoid arthritis (RA) over a 12-year period at Tan Tock Seng Hospital.
- Researchers analyzed data from 1,117 RA patients and found a total of 132 new malignancies, primarily solid-organ tumors (86.4%) and a significant number of lymphomas, with increased risks compared to the general population.
- The findings suggest that RA patients have a higher overall risk of developing malignancies, particularly lymphomas among all patients, lung cancer in males, and cervical cancer in females.
Article Abstract
Aim: This study was undertaken to determine the incidence and patterns of malignancies in rheumatoid arthritis (RA) patients in our cohort.
Methods: Between 2001 and 2013, we analyzed 1117 patients in the prospective Tan Tock Seng Hospital (TTSH) RA Registry. Patients who developed malignancies after the onset of RA were identified from this registry. Age- and sex-adjusted standardized incidence ratios (SIRs) were calculated to compare observed to expected numbers of malignancies based on data from the Singapore Cancer Registry.
Results: Out of 19 839 person-years of follow-up, 132 incident malignancies were diagnosed during the observation period. There were 114 (86.4%) solid-organ tumors and 18 (13.6%) hematological malignancies. The SIR (95% confidence interval) for all malignancies combined was 1.28 (0.88-1.87) for males and 1.21 (1.00-1.46) for females. Compared to the general population, we found a 4- to 5-fold increase in lymphoma among our RA patients compared to the general population (SIR 5.05 [1.90-13.46] for males and 3.75 [1.95-7.20] for females). The SIR of lung malignancy in male RA patients is 2.36 (1.23-4.53) and SIR of cervical malignancy in female RA patients is 3.72 (2.20-6.23).
Conclusion: There is a trend toward an overall increased malignancy risk in our RA patients compared to the general population. Specifically, there is an increased risk of lymphomas in all RA patients, lung malignancy in male patients, and cervical malignancy in female patients, compared to the general population.
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| http://dx.doi.org/10.1111/1756-185X.13655 | DOI Listing |
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