. Considering the demerits of a high-definition 2-dimensional (HD-2D) system, with its lack of stereopsis, and a conventional 3-dimensional (C-3D) system, which results in a dimmed image, we have recently developed a glasses-free 3-dimensional (GF-3D) display system for reconstruction surgeries such as video-assisted thoracic surgery (VATS) for tracheal reconstruction. . Thoracic surgeons were invited to complete thoracoscopic continuous suture of a transected porcine trachea using the HD-2D, C-3D, and GF-3D systems on separate mornings in randomized order. The duration, numbers of stitches, and distance between every 2 stitches were recorded for every procedure. The surgeons' spontaneous eye blink rate was recorded for 5 minutes before the procedure and the last 5 minutes of the procedure. . Fifteen volunteers successfully completed the tracheal reconstruction procedures in this study. Both C-3D (0.403 ± 0.064 stitch/min, < .001) and GF-3D (0.427 ± 0.079 stitch/min, < .001) showed significant advantages in speed compared with HD-2D (0.289 ± 0.065 stitch/min). Both C-3D (2.536 ± 2.223 mm, < .001) and GF-3D (2.603 ± 2.159 mm, < .001) showed significant advantages in accuracy compared with HD-2D (3.473 ± 3.403 mm). Both HD-2D (1.240 ± 0.642, < .001) and GF-3D (1.307 ± 0.894, < .001) showed significant advantages in eye fatigue compared with C-3D (3.333 ± 1.44). . All 3 available display systems are efficient for complex VATS. With the help of stereopsis, surgeons can achieve faster operation using C-3D and GF-3D systems in a thoracoscopic simulated setting. GF-3D may be a more effective display system for VATS reconstruction in terms of speed, accuracy, and eye fatigue during operations.
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Environ Sci Pollut Res Int
January 2025
Program in Biodiversity and Nature Conservation (UFJF), Institute of Biological Sciences (ICB), Federal University of Juiz de Fora (UFJF), University Campus, Martelos, Juiz de Fora, Minas Gerais, CEP, 36036-900, Brazil.
In 2020, the largest continuous wetland area on the planet, the Brazilian Pantanal, experienced an unprecedented fire that affected the entire ecosystem. Our goal was to elucidate the effects of ash presence following the fire events. We quantified the impact of ashes, collected in four Conservation Units, on soil, water, and atmosphere.
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State Key Laboratory of Advanced Drug Delivery and Release Systems, Liangzhu Laboratory, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China.
Vesicles play critical roles in cellular materials storage and signal transportation, even in the formation of organelles and cells. Natural vesicles are composed of a lipid layer that forms a membrane for the enclosure of substances inside. Here we report a coacervate vesicle formed by the liquid-liquid phase separation of cholesterol-modified DNA and histones.
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January 2025
Mechanical Engineering Department, Tianjin University, No. 135, Yaguan Road, Haihe Education Park, Jinnan District, Tianjin City, 300350, China.
The use of AR technology in image-guided neurosurgery enables visualization of lesions that are concealed deep within the brain. Accurate AR registration is required to precisely match virtual lesions with anatomical structures displayed under a microscope. The purpose of this work was to develop a real-time augmented surgical navigation system using contactless line-structured light registration, microscope calibration, and visible optical tracking.
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January 2025
Department of Pediatrics, Children's Healthcare of Atlanta, Emory University School of Medicine, Atlanta, GA, USA.
The orbitofrontal cortex (OFC) is a large cortical structure, expansive across anterior-posterior axes. It is essential for flexibly updating learned behaviors, and paradoxically, also implicated in inflexible and compulsive-like behaviors. Here, we investigated mice bred to display inflexible reward-seeking behaviors that are insensitive to action consequences.
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January 2025
Department of Pharmacy, University of Copenhagen, Universitetsparken 2, Copenhagen 2100, Denmark; Bioneer A/S, Kogle Allé 2, Hørsholm 2970, Denmark. Electronic address:
The ability to predict the absorption of exenatide (Ex), a GLP-1 analogue, after oral dosing to rats in self-nanoemulsifying drug delivery systems (SNEDDS), using in vitro methods, was assessed. Ex was complexed with soybean phosphatidylcholine (SPC) prior to loading into SNEDDS. A design of experiments (DoE) approach was employed to develop SNEDDS incorporating medium-chain triglycerides (MCT), medium-chain mono- and diglycerides (MGDG), Kolliphor® RH40, and monoacyl phosphatidylcholine.
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