AI Article Synopsis

  • This study looked at how well a tool called the MISS works to measure how much kids with certain illnesses dislike a medicine called methotrexate (MTX).
  • The researchers found that kids with juvenile idiopathic arthritis (JIA) had worse reactions to MTX than kids with acute lymphoblastic leukaemia (ALL), as shown by their MISS scores.
  • The findings suggest that the MISS can help doctors understand how kids are feeling about MTX and how to help them better.

Article Abstract

Objectives: To analyse the internal consistency of an adaption of the methotrexate intolerance severity score (MISS); and to describe and compare the level of methotrexate intolerance evaluated by the MISS in Danish children with juvenile idiopathic arthritis (JIA) or acute lymphoblastic leukaemia (ALL), treated with low-dose methotrexate (MTX).

Methods: Cross-sectional study of children diagnosed with JIA or ALL, treated with low-dose MTX, aged 9 years or above, and cognitively intact. The patient's parents completed the MISS. MTX intolerance was defined as a total MISS score above 6.

Results: We enrolled 120 children with JIA and 23 children with ALL. The MISS had a good internal consistency in the JIA group. The median MISS score was higher in the JIA group than in the ALL group (JIA: 8; ALL: 1; p<0.0001); and the JIA group had a larger proportion of MTX intolerant children than the ALL group (JIA: 73/120; ALL: 4/23; p<0.001). Within both the JIA group and the ALL group, the MISS total score was not significantly correlated with age, MTX dose or the duration of low-dose MTX treatment.

Conclusion: In the JIA group the level of MTX intolerance was higher and more attributed to anticipatory, associative and behavioural symptoms than in the ALL group. The MISS may help to uncover whether MTX intolerance is present and which aspects are affected in the individual patient, thus guiding intervention. The MISS may also be applicable within leukaemia care.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6622540PMC
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0219539PLOS

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