AI Article Synopsis
- The study investigates the male reproductive toxicity of Moringa oleifera seed extracts, specifically focusing on methanol and hexane fractions.
- Male rats were treated with these fractions for six weeks, with the methanol fraction showing a significant reduction in testosterone, sperm motility, and count, while the hexane fraction showed no adverse effects.
- Both fractions increased antioxidant levels, but the methanol fraction was linked to reproductive toxicity, suggesting a complex interaction between these extracts and male reproductive health.
Article Abstract
Objective: Aqueous extract of Moringa oleifera seeds have been reported to exert male reproductive toxicity. To elucidate the spermatoxic constituents, methanol and hexane fractions of Moringa seeds were administered to male rats.
Methods: Methanol or hexane fractions (50 and 100 mg/kg) of Moringa seeds were administered orally to male rats for six weeks, while a control group concurrently received the vehicle. Thereafter, sperm profiles were examined on a microscope while sex hormones and antioxidants levels were measured from serum samples.
Results: The methanol fraction of Moringa seeds significantly decreased testosterone, luteinizing hormone, sperm motility, and sperm count of treated rats when compared with controls. The hexane fraction of Moringa seeds had no effect on sex hormones or sperm profiles. Both methanol and hexane fractions significantly increased superoxide dismutase and catalase levels, while malondialdehyde levels decreased significantly.
Conclusion: The methanol fraction - but not the hexane fraction - of Moringa oleifera seeds induced male reproductive toxicity. By its turn, the hexane fraction had a higher antioxidant effect.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6798584 | PMC |
| http://dx.doi.org/10.5935/1518-0557.20190047 | DOI Listing |
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