AI Article Synopsis
- Historically, radiation for skin cancers on lower legs has been avoided due to concerns about increased radiation toxicity, but there's little data supporting this fear.
- A review of 25 patients treated from 2013 to 2018 showed a 65% rate of complete response and a 17% rate of Grade 3 skin toxicity after radiation, indicating moderate effectiveness and manageable risks.
- The study suggests that radiation therapy can be a viable option for patients who cannot undergo surgery, despite the risks associated with wound healing.
Article Abstract
Historically, radiation to skin cancers for the lower legs has been avoided due to the perceived increased risk of radiation toxicity (poor wound healing, radiation necrosis). However, there is a paucity of published data regarding this perceived risk. The objective was to review the risk of poor wound healing/radiation necrosis occurring post radiation and to determine rates of complete response (CR), partial response (PR), and progressive disease after radiation therapy A retrospective review of patients treated with radiation for skin cancer below the knee was undertaken from January 1, 2013 to May 31, 2018. A total of 25 patients with 39 below the knee skin sites were treated with radiation. Mean follow-up time was 19 months (range 3 months-7.2 years). Crude CR, PR and progression rates for the treated lesions were 65%, 19%, and 16% respectively. Four out of 23 (17%) patients developed Grade 3 skin toxicity. There were no grades 4 or 5 toxicities. For patients not eligible for surgery, radiation therapy is an option with a moderate chance of complete response (65%) and a 17% risk of poor wound healing/radiation necrosis.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1080/09546634.2019.1641582 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
AMBRA1 drives gastric cancer progression through regulation of tumor plasticity.
Front Immunol
December 2024
State Key Laboratory of Bioactive Molecules and Druggability Assessment, International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education (MOE) of China, School of Pharmacy, Jinan University, Guangzhou, China.
Background: Stomach adenocarcinoma (STAD) is an aggressive malignancy characterized by high tumor plasticity and heterogeneity. This study investigates the role of Autophagy and Beclin 1 Regulator 1 (AMBRA1) in regulating tumor plasticity in STAD progression.
Methods: Combined with clinical data, the pan-cancer analysis of AMBRA1 was performed to analyze the role of AMBRA1 in STAD.
Prevalence of Diabetic Foot Ulcer and Determinant Factors Among Adult Diabetic Patients Who Attend the Diabetic Follow-Up at Adwa General Hospital, Ethiopia, 2019: A Cross-Sectional Study.
Health Sci Rep
December 2024
Department of Nursing, College of Medicine and health science Adigrat University Tigray Ethiopia.
Background And Aims: Diabetic foot ulcers are the main complication of diabetes mellitus. There is limited information on the prevalence and factors of diabetic foot ulcers in Ethiopia, particularly to the study setting. The study aimed to assess the prevalence of diabetic foot ulcers and determinant factors among adult diabetic patients who attend the diabetic follow-up at Adwa General Hospital, Ethiopia, 2019.
View Article and Find Full Text PDFDevelopment of self-gelling powder combining chitosan/ bentonite nanoclay/ sodium polyacrylate for rapid hemostasis: In vitro and in vivo study.
Int J Biol Macromol
December 2024
Institute of Tissue Regeneration, Soonchunhyang University, Cheonan 31151, Republic of Korea; Department of Surgery, Soonchunhyang University Cheonan Hospital, Cheonan 31151, Republic of Korea.
Although hemostatic powders are commonly used in clinical and emergency settings, they frequently show poor absorption, raise cytotoxicity issues, and are not effective for fatal non-compressible bleeding. The purpose of this research is to create a self-gelling hemostatic powder based on chitosan, bentonite, and sodium polyacrylate (CBS) to improve the hemostatic effect. When liquid comes into contact with CBS powders, they can fuse and form a stable hydrogel in less than 30s.
View Article and Find Full Text PDFHybrid Endovascular and Direct Surgical Approach for Treatment of Penetrating Common Carotid Artery Injury: A Case Report.
NMC Case Rep J
December 2024
Department of Neurosurgery, Fukushima Medical University, Fukushima, Fukushima, Japan.
Although rare, penetrating cervical vascular injury poses significant challenges with a poor patient prognosis, often attributed to severe hemorrhage and accompanying injuries. We encountered a case of hemorrhagic shock resulting from a penetrating injury to the common carotid artery (CCA), which was successfully managed using a combination of endovascular therapy and direct surgical intervention. A 23-year-old man presented with a self-inflicted stab wound on the left side of his neck from a kitchen knife.
View Article and Find Full Text PDFConstruction and clinical application of a risk model based on N6-methyladenosine regulators for colorectal cancer.
PeerJ
December 2024
Cancer Diagnosis and Treatment Research Center, The First Affiliated Hospital of Jinan University, Guangzhou, China.
Background: Colorectal cancer (CRC) shows a high incidence in developed countries. This study established a prognosis signature based on N6-methyladenosine (m6A) regulators involved in CRC progression.
Method: The bulk RNA-seq data from the Atlas and Compass of Immune-Colon cancer-Microbiome interactions (AC-ICAM) and GSE33113 CRC datasets were obtained from the cBioportal and GEO databases, and a total of 21 m6A regulators genes were collected from a previous study.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!