AI Article Synopsis
- A study was conducted to assess the impact of serum globulin (GLB) levels on the prognosis of patients with hepatocellular carcinoma (HCC) who underwent liver resection, as previous studies had not extensively explored this relationship.
- The research comprised two cohorts: a training cohort of 210 patients and a validation cohort of 100 patients, utilizing survival curves and statistical tests to determine prognostic factors.
- Results indicated that high serum GLB levels correlate with poorer cancer-specific survival, while high albumin levels are associated with better outcomes, suggesting that GLB could serve as a useful clinical biomarker in HCC prognosis.
Article Abstract
: Serum globulin (GLB), albumin (ALB) and albumin/globulin ratio (AGR) have been reported as prognosis related factors for certain malignancies; however, the prognostic value of globulin (GLB) in hepatocellular carcinoma (HCC) has rarely been studied. This study was performed to evaluate whether GLB analysis could be applied for the prediction of the prognosis of patients received liver resection. : A training cohort study involving 210 HCC patients undergoing curative liver resection between January 2007 and December 2012, and a validation cohort involving 100 HCC patients contemporaneously undergoing curative liver resection in another set were recruited. The survival curves were graphed and log-rank test was performed to analyze the differences between the curves. The cutoff value was selected by X-title program. : Univariate and multivariate analysis indicated that high serum GLB level is a risk factor for poor cancer-specific survival (CSS) (P < 0.05). Conversely, high ALB level is a prediction for favor CSS (P = 0.010). : We identified the preoperative high GLB level as a prognostic risk factor for patients after treatment of liver cancer resection. This easily obtained variable may act as an available clinical biomarker to predict the prognosis of such patients.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6603401 | PMC |
| http://dx.doi.org/10.7150/jca.29499 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Psychosocial Stress at Work and Risks for Burnout Among Hotel Workers.
J Occup Environ Med
November 2024
University of Michigan, School of Nursing, Ann Arbor, MI, USA.
Objective: Hotel workers are at risk for burnout. We tested the association between effort-reward imbalance (ERI) and burnout.
Methods: Participants were recruited through social media and completed an online survey.
Association between the occupation of pregnant women's partners and risks of infant low birth weight and preterm birth in a prospective birth cohort: the Japan Environment and Children's Study.
J Occup Environ Med
November 2024
Center for Environmental and Health Sciences, Hokkaido University, Sapporo, Japan.
Objective: We examined the association between the occupations of pregnant women's partners and infant low birth weight (LBW) and preterm birth (PB).
Methods: Birth outcome data were collected from 46,540 participants enrolled in the Japan Environment and Children's Study. Participants were recruited from January 2011 to March 2014.
Metabolic Dysfunction-Associated Steatotic Liver Disease.
Ann Intern Med
January 2025
Department of Medicine, Division of Gastroenterology and Hepatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts (S.M.J.A., M.L.).
Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common chronic liver disease in the United States. It is characterized by steatosis in the liver and is potentially reversible. Risk factors include obesity, type 2 mellitus, and other metabolic disorders.
View Article and Find Full Text PDFBranch retinal vein occlusion and Valsalva manoeuvre in wind instrument players and singers.
Clin Exp Optom
January 2025
Department of Optometry and Vision Sciences, The University of Melbourne, Parkville, Australia.
Clinical Relevance: There are many recognised risk factors for retinal vein occlusions. It is plausible that musicians who play wind instruments or use their voice as their primary instrument may be at increased risk of branch retinal vein occlusions through repeated Valsalva manoeuvre.
Background: Repeated valsalva manoeuvres are commonly performed by musicians using high resistance wind instruments.
Concerns on Potential Risk of Roxadustat in Promoting Tumor Progression: Double-Edged Sword of Hypoxia-Inducible Factor-1α Activation.
J Clin Oncol
January 2025
Jing Tan, MD, The Third People's Hospital of Chengdu, Chengdu, Sichuan, China; Lin Chen, MM, School of Medicine, North Scihuan Medical College, Nanchong, Sichuan, China; and Rui Zhu, MM, The Third People's Hospital of Chengdu, Chengdu, Sichuan, China.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!