Background: Premature luteinization (PL) is defined as a premature rise in serum progesterone concentration on or before the day of ovulation trigger with human chorionic gonadotropin. The incidence of PL varies between 5% and 30% during fertilization and embryo transfer (IVF-ET).
Materials And Methods: The prospective observational study comprising 380 patients undergoing IVF-ET. Blood samples were collected for serum progesterone level estimation on the day of ovulation trigger. Ovum pickup was done 36 h later and serum progesterone levels were correlated with IVF-ET outcome.
Study Outcome: To correlate serum progesterone level on the day of ovulation trigger during IVF and its effect on treatment outcome.
Results: Mean serum progesterone level in the positive pregnancy group and negative pregnancy group was 0.892 ± 0.752 ng/ml and 0.91 ± 0.688 ng/ml, respectively ( = 0.961). The overall incidence of PL was 12.8% with 12.7% and 13.6% in the agonist and antagonist protocol respectively ( = 0.9001). PL incidence was 13.5% and 13.4% in positive pregnancy and negative pregnancy group ( = 0.223).
Conclusion: PL has been associated with 12.8% of the IVF cycles. There was no statistically significant difference observed in the incidence of PL between different IVF stimulation protocols. PL does not seem to affect IVF outcome.
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| http://dx.doi.org/10.4103/jhrs.JHRS_115_18 | DOI Listing |
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