AI Article Synopsis
- * Sixty CCHF patients were studied, showing significantly higher levels of ET-1, Ang-2, and Tie-2 compared to a control group, indicating a biological response to the severe illness.
- * The findings suggest that elevated ET-1 and Tie-2 levels are linked to more severe outcomes in CCHF, while Ang-2 levels inversely correlate with disease severity, highlighting their potential as prognostic markers for treatment
Article Abstract
Background/aim: Crimean-Congo hemorrhagic fever (CCHF) is a serious illness characterized by fever and hemorrhage. Endothelin-1 (ET-1), angiopoietin-2 (Ang-2), and endothelial cell-specific receptor tyrosine kinase (Tie-2) are believed to be important markers of the pathogenesis, clinical course, and prognosis of the disease. The aim of this study was to determine ET-1, Ang-2, and Tie-2 levels in adults with CCHF and investigate the associations between these markers and pathogenesis and disease course.
Materials And Methods: Sixty CCHF patients were included in the study. The patients were classified according to disease severity criteria and Ang-2, Tie-2, and ET-1 levels were compared.
Results: Mean serum ET-1 level was 36.62 ± 27.99 pg/mL in the patient group and 3.70 ± 4.71 pg/mL in the control group (P = 0.001). Mean serum Ang-2 levels were 2511.18 ± 1018.64 pg/mL in the patient group and 3570.76 ± 209.52 pg/mL in the control group (P = 0.001). Mean serum Tie-2 levels were 7.35 ± 7.75 ng/mL in the patient group and 0.67 ± 1.26 ng/mL in the control group (P = 0.001).
Conclusion: Elevated ET-1 and Tie-2 levels were associated with more severe disease course, while Ang-2 level was negatively correlated with severity in adult CCHF patients. ET-1, Tie-2, and Ang-2 levels are important prognostic parameters in CCHF and may contribute significantly to treatment and follow-up.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7018223 | PMC |
| http://dx.doi.org/10.3906/sag-1812-10 | DOI Listing |
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