AI Article Synopsis
- * Thpo signaling helps in the self-renewal of hematopoietic stem cells (HSCs), which has led to the creation of Thpo mimetic drugs aimed at treating diseases like aplastic anemia where HSC function is impaired.
- * This review focuses on the details of how Thpo-Mpl signaling influences the regulation and function of HSCs in the body.
Article Abstract
Thrombopoietin (Thpo) and its receptor myeloid proliferative leukemia (Mpl) were initially identified as the cytokine signaling that stimulates megakaryopoiesis and platelet production. However, Thpo-Mpl signaling has also been widely characterized as one of the few cytokine systems that directly regulates hematopoietic stem and progenitor cells. The ability of Thpo signaling to stimulate hematopoietic stem cell (HSC) self-renewal has led to the development and utilization of Thpo mimetic drugs to treat hematopoietic diseases with restricted function of HSCs, such as aplastic anemia. This review will cover the mechanisms by which Thpo-Mpl signaling regulates HSCs.
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| http://dx.doi.org/10.1111/nyas.14169 | DOI Listing |
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