Mapping evidence on tuberculosis active case finding policies, strategies, and interventions for tuberculosis key populations: a systematic scoping review protocol.

Background: Early diagnosis and treatment of tuberculosis (TB) have been shown to reduce the impact of TB illness particularly, among TB key populations such as people living with HIV/AIDS, prisoners, refugees, migrants, displaced populations, survivors of TB illness, and indigenous populations. We propose to conduct a systematic scoping review to map global evidence on active tuberculosis case finding policies, strategies, and interventions for TB key populations.

Method And Analysis: This study will be guided by the scoping review framework, proposed by Arksey and O'Malley. A comprehensive literature search will be performed in the following electronic databases: PubMed, SCOPUS, Web of Science, Science Direct, and EBSCOhost (Academic search complete, PsycINFO, Health Sources, CINAHL, and MEDLINE with full text). Primary studies both published in peer-reviewed journals and grey literature such as unpublished studies, thesis, and studies in press addressing our research question will be included. To reduce selection bias, two independent reviewers will perform title, abstract, and full article screening in parallel. Also, data extraction from the included studies will be conducted by two independent reviewers. We will use NVivo version 11 software to extract the outcomes relevant to answering the research question from the included studies using a content thematic analysis. The results of this proposed study will be presented according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis: Extension for Scoping Review (PRISMA-ScR). The mixed methods assessment tool version 2018 will be employed for quality appraisal of the included studies.

Discussion: We anticipate that the mapped evidence will help reveal diverse active TB case finding policies, strategies, and interventions to help inform future adoption and implementation to reduce TB missing cases worldwide. We also anticipated that the results of the proposed scoping review will help reveal research gaps, which can be addressed to ensure early detection and treatment of TB among key populations. The proposed study will may as well contribute to healthcare systems strengthening and improve research in TB key populations.