AI Article Synopsis
- Hydrocarbon stapled peptides are potential drugs that can block interactions between proteins inside cells.
- A new method using mRNA display is created to quickly discover these stapled peptides, utilizing α-methyl cysteine and m-dibromoxylene for cyclization.
- The research specifically aims to find a peptide that can effectively bind to the HPV16 E2 protein, which is relevant for HPV-related diseases.
Article Abstract
Hydrocarbon stapled peptides are promising therapeutics for inhibition of intracellular protein-protein interactions. Here we develop a new high-throughput strategy for hydrocarbon stapled peptide discovery based on mRNA display of peptides containing α-methyl cysteine and cyclized with m-dibromoxylene. We focus on development of a peptide binder to the HPV16 E2 protein.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7077329 | PMC |
| http://dx.doi.org/10.1039/c8cc10192b | DOI Listing |
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