Herein, we report the DNA interaction studies of rhenium(I) and -(V) compounds with Schiff base chelates encompassing biologically relevant moieties. More specifically, the DNA interaction capabilities of these rhenium complexes were probed using Gel Electrophoresis and Calf Thymus-DNA titrations monitored by temperature-controlled electronic spectroscopy. The DNA binding modes of the metal compounds were corroborated by molecular docking simulations. In addition, the synthesis and characterization of a novel tricarbonyl rhenium(I) compound, -[Re(chrs)(CO)Br], (chrs = {3-{[(2-hydroxyphenyl)imino]methyl}-4-chromen-4-one) are reported.
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| http://dx.doi.org/10.1080/15257770.2019.1639058 | DOI Listing |
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