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| http://dx.doi.org/10.1111/bph.14785 | DOI Listing |
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Elucidating how trace gases interact with ice surfaces utilizing sum frequency generation spectroscopy.
Faraday Discuss
March 2025
Boise State University, Department of Chemistry and Biochemistry, 1910 University Drive, Boise, Idaho, 83702, USA.
The interaction between ice surfaces and trace gases plays a significant role in atmospheric chemistry, such as chemical and photochemical reactions contributing to ozone depletion and secondary aerosol formation. The study of molecular-level properties of the ice surface and small organic molecule adsorption, are essential to understand the impact of hosting these molecules and further chemical reactions. To capture a molecular understanding of the interface, the use of a surface selective technique, such as sum frequency generation (SFG) spectroscopy, is crucial to probe ice surfaces and observe the adsorption of molecules on ice surfaces.
View Article and Find Full Text PDFThe role of surgical resection of the primary tumor in metastatic upper tract urothelial carcinoma: a systematic review and meta-analysis.
Curr Opin Urol
March 2025
Department of Urology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria.
Purpose Of Review: To evaluate the role of extirpative surgery for the primary tumor in metastatic upper tract urothelial carcinoma (mUTUC).
Recent Findings: The PubMed, Web of Science, and Cochrane Library were searched on July 2024 to identify relevant studies according to the Preferred Reporting Items for Systematic Review (PRISMA) statement. Studies were eligible for analysis if they compared oncologic outcomes between mUTUC patients who underwent surgical resection of the primary tumor and patients who did not.
The Dual Role of Active Site Hydroxylated Residue in Peroxiredoxin Sulfinylation Catalysis.
Antioxid Redox Signal
March 2025
Université de Lorraine, CNRS, IMoPA, F-54000 Nancy, France.
Peroxiredoxins (Prx) are ubiquitous Cys peroxidases regulated by sulfinylation, a modification that occurs when the sulfenic acid generated on the catalytic Cys by peroxide reduction reacts with a second molecule of peroxide. In the Prx1 family, sulfinylation sensitivity is controlled by competition between a structural transition from a fully folded (FF) to locally unfolded (LU) conformation and the chemical step of sulfinylation. The initial peroxide reduction relies on a conserved catalytic hydroxylated residue that allows peroxide optimal activation.
View Article and Find Full Text PDFReporting a Homozygous Case of Neurodevelopmental Disorder Associated With a Novel PRPF8 Variant.
Mol Genet Genomic Med
March 2025
Department of Medical Genetics, University of British Columbia (UBC), Vancouver, British Columbia, Canada.
Background: While recently identified heterozygous PRPF8 variants have been linked to various human diseases, their role in neurodevelopmental disorders (NDDs) remains ambiguous. This study investigates the potential association between homozygous PRPF8 variants and NDDs. Most PRPF8 variants are primarily associated with retinal diseases; however, we analyze a family with multiple members diagnosed with NDDs.
View Article and Find Full Text PDFA NAC transcription factor and a MADS-box protein antagonistically regulate sucrose accumulation in strawberry receptacles.
Plant Physiol
March 2025
Shanghai Collaborative Innovation Center of Agri-Seeds, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, China.
Sugar accumulation during fruit ripening is an essential physiological change that influences fruit quality. While NAC transcription factors are recognized for their role in modulating strawberry (Fragaria × ananassa) fruit ripening, their specific contributions to sugar accumulation have remained largely unexplored. This study identified FvNAC073, a NAC transcription factor, as a key regulator that not only exhibits a gradual increase in gene expression during fruit ripening but also enhances the accumulation of sucrose.
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