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The Stromal and Immune Landscape of Colorectal Cancer Progression during Anti-EGFR Therapy. | LitMetric

The Stromal and Immune Landscape of Colorectal Cancer Progression during Anti-EGFR Therapy.

Cancer Cell

Department of Oncology, University of Torino, 10060 Candiolo, Torino, Italy; Candiolo Cancer Institute-FPO IRCCS, 10060 Candiolo, Torino, Italy. Electronic address:

Published: July 2019

In this issue of Cancer Cell, Woolston et al. show that colorectal cancers that become refractory to initially effective anti-EGFR therapy contain an abundance of stromal and immune cells, irrespective of the contextual presence of resistance-conferring mutations. This reconfiguration puts forward therapeutic opportunities for patients who relapse on EGFR-targeting treatment.

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Source
http://dx.doi.org/10.1016/j.ccell.2019.06.001DOI Listing

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