Correction for 'The effects of nattokinase supplementation on collagen-epinephrine closure time, prothrombin time and activated partial thromboplastin time in nondiabetic and hypercholesterolemic subjects' by Hye Jin Yoo et al., Food Funct., 2019, 10, 2888-2893.
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A Nattokinase-Loaded Nanozyme for Alleviating Acute Myocardial Infarction via Thrombolysis and Antioxidation.
Adv Healthc Mater
December 2024
Fuwai Central-China Cardiovascular Hospital, Central China Fuwai Hospital of Zhengzhou University, Zhengzhou, 450046, China.
Acute myocardial infarction (MI) induced by thrombus formation is a prevalent cardiovascular disorder, and thrombolytic therapy continues to be a principal treatment modality. Prior research indicates a substantial association among MI, thrombosis, and the activation of oxidative stress pathways. The effectiveness of current thrombolytic drugs is relatively constrained, and the need for innovative and versatile thrombolytic medications remains critical.
View Article and Find Full Text PDFFermentation with Bacillus natto and Bifidobacterium improves the functional, physicochemical properties, and taste qualities of coix seed-natto.
Food Res Int
November 2024
Guizhou Light Industry Vocational and Technical College, Guiyang, 550025, PR China. Electronic address:
Coix seed-natto (CS-natto) is a nutritious food rich in various functional components such as nattokinase (NK), and the strains' fermentation is crucial for enhancing its quality. This work utilized Bacillus natto GUTU09 (B9) and Bifidobacterium animalis subsp. lactis BLH1 or BLH6 to ferment soybeans that were soaked in a saccharified liquid made from CS, resulting in the preparation of CS-natto, studied the physicochemical and functional characteristics during fermentation, and analyzed the correlation of various indicators.
View Article and Find Full Text PDF"Nattokinase as a potential therapeutic agent for preventing blood-brain barrier dysfunction in neurodegenerative disorders".
Brain Res
February 2025
Division of Neuroscience, Department of Pharmacology, Smt. Kishoritai Bhoyar College of Pharmacy, New Kamptee, Nagpur (M.S.) 441 002, India. Electronic address:
Neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis are characterized by progressive destruction of neurons and cognitive impairment, and thorough studies have provided evidence that these pathologies have a close relationship to the failure of the blood-brain barrier (BBB). Nattokinase (NK), a protease found in fermented soybeans, has been extensively studied because it displays powerful neuroprotective abilities, which is why current research was reviewed in the present article. It was concluded that there is enough evidence in preclinical studies using experimental animals that NK supplementation can alleviate the condition related to BBB dysfunction, reduce brain inflammation, and improve cognitive ability.
View Article and Find Full Text PDFPrecisely Controlling the Activation of an Iron-Locked Drug Generator in the Liver Sinusoid to Enhance Barrier Penetration and Reduction of Liver Fibrosis.
J Am Chem Soc
December 2024
School of Pharmacy, Anhui University of Chinese Medicine, Hefei 230031, China.
Article Synopsis
- - The text discusses challenges in delivering antifibrotic drugs to the liver due to physical barriers and clearance mechanisms, prompting the development of a new delivery strategy aimed at treating liver fibrosis.
- - This strategy involves a combination of a drug generator called Pro-HAase, which is injected, and an oral iron chelator named deferasirox (DFX), creating a targeted release of antifibrotic agents specifically in the fibrotic liver.
- - The approach effectively reverses liver fibrosis while minimizing toxicity related to residual iron, showcasing a sophisticated method for overcoming drug delivery barriers in liver treatment, potentially guiding future designs for similar nanomaterial systems.
Effect of Nattokinase in D-galactose- and Aluminum Chloride-induced Alzheimer's Disease Model of Rat.
In Vivo
October 2024
School of Pharmacy, Faculty of Pharmacy and Pharmaceutical Sciences, Josai University, Saitama, Japan;
Background/aim: Alzheimer's disease (AD) is the most common form of dementia worldwide. Nattokinase is a serine protease extracellularly produced by natto, a fermented product of Bacillus subtilis var. natto.
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