AI Article Synopsis
- The Kidd Lab has developed a set of 55 ancestry informative SNPs (AISNPs) that are being used to analyze various populations globally, emphasizing their effectiveness as a genetic marker panel.
- A reference database has been created to infer relationships between new population samples, particularly focusing on populations from Southwest Asia and the Mediterranean, many of which lack prior analysis for forensic markers.
- The total number of analyzed population samples has increased to 164, enhancing the overall value of the database by integrating additional data from various world regions.
Article Abstract
The set of 55 ancestry informative SNPs (AISNPs) originally developed by the Kidd Lab has been studied on a large number of populations and continues to be applied to new population samples. The existing reference database of population samples allows the relationships of new population samples to be inferred on a global level. Analyses show that these autosomal markers constitute one of the better panels of AISNPs. Continuing to build this reference database enhances its value. Because more than half of the 25 ethnic groups recently studied with these AISNPs are from Southwest Asia and the Mediterranean region, we present here various analyses focused on populations from these regions along with selected reference populations from nearby regions where genotype data are available. Many of these ethnic groups have not been previously studied for forensic markers. Data on populations from other world regions have also been added to the database but are not included in these focused analyses. The new population samples added to ALFRED and FROG-kb increase the total to 164 population samples that have been studied for all 55 AISNPs.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6871633 | PMC |
| http://dx.doi.org/10.1038/s41431-019-0466-6 | DOI Listing |
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