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Reduction of Chronic Fatigue Through Transcranial Direct Current Stimulation and Low-Intensity Aerobic Exercise: A Case Study of Two Patients With Granulomatosis With Polyangiitis.
Cureus
November 2024
Rheumatology, Faculdade de Medicina da Universidade de São Paulo (FMUSP), Sao Paulo, BRA.
Granulomatosis with polyangiitis (GPA) is a systemic vasculitis that can lead to persistent pain and fatigue, significantly impacting patients' quality of life. This study assessed the effects of transcranial direct current stimulation (tDCS) combined with aerobic exercise as a non-pharmacological intervention for managing fatigue in GPA patients. Two patients were randomly assigned to receive either active tDCS or simulated tDCS stimulation (sham) during low-intensity aerobic exercise.
View Article and Find Full Text PDFWide-field fluorescein angiography findings in active anterior scleritis.
J Ophthalmic Inflamm Infect
December 2024
Inflammatory Eye Disease Clinic, Asociación para Evitar la Ceguera en México, Vicente Garcia Torres No. 46 Coyoacán, Mexico City, 04030, Mexico.
Objective: Describe the proportion of patients with wide-field fluorescein angiographic (WFFA) findings in patients with active anterior scleritis.
Methods: An observational, descriptive, cross-sectional study of the WFFA findings of patients with active anterior scleritis including nodular, diffuse, or necrotizing involvement was performed. Studies were performed with the Heidelberg Spectralis module (102º).
Granulomatosis With Polyangiitis in an Autistic Patient With Depression: Challenges in Diagnosis and Management.
Cureus
November 2024
Rheumatology, University Hospital of North Durham, Durham, GBR.
A male patient in his 30s with autism and depression presented to the emergency department with joint pain, a petechial/purpuric rash, sputum production, hemoptysis, and epistaxis. His mother reported a family history of autoimmune conditions. Examination revealed a non-blanching petechial/purpuric rash and tenderness in the feet and ankles.
View Article and Find Full Text PDFUnveiling the Uncommon: A Case of Eosinophilic Granulomatosis With Polyangiitis Featuring Atypical Presentation and Diagnostic Challenges.
Cureus
October 2024
Internal Medicine, Unidade Local de Saúde Gaia Espinho, Vila Nova de Gaia, PRT.
Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare necrotizing vasculitis affecting small- to medium-sized vessels that can manifest in a multisystemic manner. While the classic triad of rhinosinusitis, asthma, and eosinophilia is commonly associated, it is essential to recognize that these features are not mandatory for diagnosis. We present a case of a 61-year-old woman with a unique EGPA manifestation who was hospitalized because of a seven-month history of weight loss, asthenia, epigastric abdominal pain, peripheral eosinophilia, and paresthesia in the left feet and hand.
View Article and Find Full Text PDFMechanisms and Screening for Atherosclerosis in Adults With Vasculitis.
Arterioscler Thromb Vasc Biol
January 2025
Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston (M.J.H., Z.S.W.).
Vascular inflammation is a hallmark of both primary systemic vasculitis and atherosclerosis. As such, cardiovascular events are common in patients with vasculitis and likely due to both direct vascular inflammation and accelerated atherosclerosis. Direct cardiac involvement is possible in all vasculitides, though more commonly described in Takayasu arteritis, polyarteritis nodosa, and eosinophilic granulomatosis with polyangiitis.
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