Comfort as an essential parameter for running footwear is gaining importance in footwear research and development, and has also been proposed to decrease injury rate and improve metabolic demand in the paradigm of the comfort filter. The aims of this study were to determine differences in oxygen consumption and biomechanical variables associated with lower extremity injuries in response to running shoes of differing comfort. Fifteen male runners attended two testing sessions including an incremental lactate threshold test, a comfort assessment and treadmill running trials for the biomechanical and physiological measurements. Statistical analyses were performed on oxygen consumption, spatio-temporal variables including foot-ground angle and coupling angle variability of 12 couplings in five stride phases. No decrease in oxygen consumption was found in the most preferred shoe condition. Investigation of potential biomechanical contributors to changes in metabolic demands revealed differences in the stride rate between the most and least preferred condition. In coupling angle variability analyses, only one coupling (ankle dorsiflexion/plantarflexion to knee varus/valgus) yielded a significant difference between conditions in the phase including the touch down. Based on the findings of this study, previous suggestions regarding positive effects of enhanced footwear comfort during running cannot be supported - neither on economy nor on injury prevention perspective. However, a prospective study of lower extremity injury combined with measurements of biomechanical and physiological variables seems to be required for a definite support or contradiction of the comfort filter.
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http://dx.doi.org/10.1080/17461391.2019.1640288 | DOI Listing |
PLoS One
January 2025
Department of Orthopedics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Ratchathewi, Bangkok, Thailand.
Among control methods for robotic exoskeletons, biologically inspired control based on central pattern generators (CPGs) offer a promising approach to generate natural and robust walking patterns. Compared to other approaches, like model-based and machine learning-based control, the biologically inspired control provides robustness to perturbations, requires less computational power, and does not need system models or large learning datasets. While it has shown effectiveness, a comprehensive evaluation of its user experience is lacking.
View Article and Find Full Text PDFJ Cell Biol
March 2025
Department of Molecular Biosciences, University of Texas at Austin, Austin, TX, USA.
The interplay between ribosomal protein (RP) composition and mitochondrial function is essential for energy homeostasis. Balanced RP production optimizes protein synthesis while minimizing energy costs, but its impact on mitochondrial functionality remains unclear. Here, we investigated haploinsufficiency for RP genes (rps-10, rpl-5, rpl-33, and rps-23) in Caenorhabditis elegans and corresponding reductions in human lymphoblast cells.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
University of Kansas Alzheimer's Disease Research Center, Fairway, KS, USA.
Background: Cardiorespiratory fitness (CRF) has been repeatedly linked to healthy brain and cognitive outcomes in aging. Treadmill-based graded maximal exercise testing (GXT) is a common technique for measuring CRF in exercise studies. Because it is often challenging for older adults to reach the commonly accepted criterion measure of oxygen consumption, alternate, submaximal measures have been explored.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Laboratory of Clinical Investigation, National Institute on Aging, Intramural Research Program, Baltimore, MD, USA.
Background: Age-related white matter (WM) deterioration has been associated with several neurodegenerative diseases, including Alzheimer's disease. Studies suggest that cardiorespiratory fitness (CRF) is important in preserving WM structure and function. However, clinical investigations of the relationship between myelin integrity and CRF are lacking.
View Article and Find Full Text PDFKardiologiia
December 2024
Research Institute of Cardiology, Branch of the Tomsk National Research Medical Center of the Russian Academy of Sciences, Tomsk.
Aim: Comparative assessment of structural changes in cardiomyocyte mitochondria of the right atrial appendage and the mitochondrial respiratory function in peripheral blood leukocytes in a cohort of patients after acute decompensated heart failure (ADHF) and with stable chronic heart failure of ischemic etiology with reduced ejection fraction (CHFrEF) or moderately reduced ejection fraction (CHFmrEF) of the left ventricle.
Material And Methods: The study analyzed 40 micrographs of right atrial appendage cardiomyocytes obtained from 12 patients with CHFrEF and CHFmrEF. The study protocol was registered on ClinicalTrials.
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