AI Article Synopsis
- Advances in understanding inflammatory bowel disease (IBD) benefit from studies using human intestinal tissue, particularly from pediatric subjects.
- Enrolling children in IBD research is crucial as this population is often underserved, allowing for better insights into their unique needs.
- Institutional review boards (IRBs) must carefully evaluate the benefits of research biopsies against potential risks, especially given the limited safety data on obtaining these biopsies in children.
Article Abstract
Advancing the understanding of inflammatory bowel disease (IBD) pathogenesis has been facilitated by mechanistic studies that require human intestinal tissue. Enrolling pediatric subjects into these studies improves our knowledge of IBD in this underserved population. Given the additional research protections granted to children, institutional review boards (IRBs) must weigh the benefit of obtaining research biopsies against perceived risks. Although obtaining clinical biopsies from children is generally considered safe, there are only limited data on the safety of obtaining research biopsies in children..
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| http://dx.doi.org/10.1016/j.cgh.2019.06.040 | DOI Listing |
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