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Clinical study on the utility of allergy tests to detect IgE-mediated anaphylaxis after diclofenac etalhyaluronate administration.
Mod Rheumatol
October 2024
Department of Allergology, Fujita Health University School of Medicine, Nagoya, Japan.
Objectives: This study was conducted to investigate factors involved in anaphylaxis related to diclofenac etalhyaluronate (DEH) [product name: Joyclu® (JCL)] (containing DEH and macrogol 400), which is used to treat patients with osteoarthritis.
Methods: Patients with osteoarthritis were divided into two groups that had (experienced patients) or had not experienced anaphylactic symptoms after JCL administration (non-experienced patients). Five tests performed to assess factors related to anaphylaxis consisted of a skin prick test (SPT) as the primary endpoint and the other tests including basophil activation test, allergen-specific IgE (sIgE) tests using enzyme-linked immunosorbent assay or immunochromatographic kits, and genetic study were secondary endpoints.
Polysorbate 80-containing ionizable lipid nanoparticles for mRNA delivery.
Biomater Sci
October 2024
State Key Laboratory of Urban Water Resource and Environment, School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin, 150001, China.
Article Synopsis
- This study highlights the use of polysorbate 80 (PS80) as an alternative to polyethylene glycol (PEG) in ionizable lipid nanoparticles (iLNPs) for mRNA vaccine delivery, addressing PEG's potential to cause immune reactions and decreased efficacy.
- PS80-iLNPs showed improved stealth properties—1.14 times greater than PEG-iLNPs—which helps them evade the immune system, and they also demonstrated better cell viability, being 1.12 times higher at a lipid concentration of 50 μg/mL.
- In terms of serum resistance, while PEG-iLNPs experienced a 44.97% reduction in uptake, PS80
Anaphylaxis after Treatment with an Endodontic Material Containing Polyethylene Glycol.
J Endod
November 2024
Dental Biomaterials Adverse Reaction Unit, NORCE Norwegian Research Centre AS, Bergen, Norway.
Polyethylene glycol (PEG) is sometimes included in temporary endodontic filling materials to modify viscosity. PEG is considered a low hazard chemical, but parenteral PEG exposure is associated with a risk of anaphylaxis. We report 2 cases of anaphylaxis after treatment with an endodontic temporary filling material containing PEG.
View Article and Find Full Text PDFPEGylated liposomes for diagnosis of polyethylene glycol allergy.
J Allergy Clin Immunol
August 2024
Adelaide Medical School, University of Adelaide, Adelaide, Australia; Immunology Directorate, SA Pathology, Adelaide, Australia; Department of Allergy and Immunology, Royal Adelaide Hospital, Adelaide, Australia. Electronic address:
Background: Polyethylene glycol (PEG) is a nonprotein polymer that is present in its native (unbound) form as an excipient in a range of products. It is increasingly being utilized clinically in the form of PEGylated liposomal medications and vaccines. PEG is the cause of anaphylaxis in a small percentage of drug reactions; however, diagnosis of PEG allergy is complicated by the variable and poor diagnostic performance of current skin testing protocols.
View Article and Find Full Text PDFKnowledge mapping and global trends of drug hypersensitivity from 2013 to 2023: A bibliometric analysis.
Immun Inflamm Dis
April 2024
Department of Pathology, School of Forensic Medicine, Shanxi Medical University, Taiyuan, China.
Article Synopsis
- Drug hypersensitivity is a growing global health concern, with research trends indicating a significant rise in its prevalence across various populations.
- A study utilizing data from the Web of Science Core Collection mapped out co-occurrence relationships among countries, institutions, authors, and key terms, revealing the U.S. and China as top contributors to the research.
- Future research will focus on developing algorithms for diagnosis and understanding the immunological mechanisms behind drug hypersensitivity, particularly in relation to anaphylaxis caused by polyethylene glycols.
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