AI Article Synopsis
- A recent study (Yamada et al., Nature, 2019) investigated how changes in genome architecture affect mature neurons' gene expression and functionality.
- The research focused on the cerebellum, taking advantage of its unique characteristics to study specific cell types.
- Findings showed that chromatin structure changes in response to neural activity influence gene transcription, playing a role in sensorimotor learning.
Article Abstract
Whether dynamic changes in genome architecture underlie transcriptional and functional plasticity in mature neurons has been technically challenging to address. A recent study (Yamada et al., Nature, 2019) exploited experimental advantages of the cerebellum to reveal cell type-specific changes in chromatin architecture that coordinate neural activity-induced changes in gene transcription and contribute to sensorimotor learning.
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| http://dx.doi.org/10.1016/j.tins.2019.06.002 | DOI Listing |
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