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Drug and Venom Allergy in Mastocytosis.
Immunol Allergy Clin North Am
November 2023
Division of Allergy and Clinical Immunology, Brigham and Women's Hospital, 41 Avenue Louis Pasteur, Alumni Hall, Room 303, Boston, MA 02115, USA; Harvard Medical School, 41 Avenue Louis Pasteur, Alumni Hall, Room 303, Boston, MA 02115, USA.
Patients with mastocytosis have an increased risk for mast cell activation events including anaphylaxis when exposed to certain drugs and Hymenoptera venom. Hypotension and cardiovascular collapse without skin or other systemic manifestations can occur after Hymenoptera stings, during the perioperative period, and after exposure to nonsteroidal ntiinflammatory drugs, opioids, and other mast cell activating medications, including vancomycin and quinolones. This chapter reviews the epidemiology, mechanisms, diagnosis, management, and treatment options for Hymenoptera venom and drug-induced reactions in patients with mastocytosis.
View Article and Find Full Text PDFMRGPRX2, drug pseudoallergies, inflammatory diseases, mechanisms and distinguishing MRGPRX2- and IgE/FcεRI-mediated events.
Br J Clin Pharmacol
November 2023
Royal North Shore Hospital of Sydney, Kolling Institute of Medical Research, Sydney, New South Wales, Australia.
Article Synopsis
- MRGPRX2 is a novel receptor found in human skin mast cells that triggers adverse reactions like itching and inflammation without needing antibodies.
- This receptor plays a key role in pseudoallergic drug reactions, which can be confused with immune-mediated reactions, making it crucial for clinicians to differentiate between the two.
- The text outlines specific drugs linked to MRGPRX2 and highlights its importance in diagnosing inflammatory conditions such as chronic urticaria and atopic dermatitis, and suggests that new testing approaches might improve understanding and safety in drug administration.
MRGPRX2 signaling and skin test results.
J Allergy Clin Immunol Pract
January 2020
Division of Allergy, Asthma & Immunology, Scripps Clinic, San Diego, Calif. Electronic address:
Mastocytosis, Quinolones, MRGPRX2, and Anaphylaxis.
J Allergy Clin Immunol Pract
May 2020
Division of Allergy, Mayo Clinic, Rochester, Minn. Electronic address:
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