In this work, we investigated the potential effects of nontyphoidal infection on autoantibody (AA) formation. The titer and profiles of autoantibodies in the sera of patients with acute salmonellosis due to serovar Typhimurium ( Typhimurium) or serovar Enteritidis ( Enteritidis) infection, as well as in convalescent patients, were determined with indirect immunofluorescence. A significant increase of autoantibodies in acute diseases caused by both serotypes of and during post infection by Enteritidis was detected. Antibody profile analysis by multivariate statistics revealed that this increase was non-specific and was not dependent on the infectious agent or disease stage. The results obtained suggest that nontyphoidal infection contributes to the generation of autoantibodies and may play a role in autoimmune disease.
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| http://dx.doi.org/10.3390/pathogens8030096 | DOI Listing |
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