AI Article Synopsis
- Exosomes are tiny bubbles released by all kinds of cells and they help cells communicate with each other.
- Recent research is focused on how exosomes are connected to colorectal cancer (CRC) and how they affect the tumor environment and the immune system.
- Scientists believe exosomes could be helpful for new cancer tests and treatments, but more research is needed before they can be used in hospitals.
Article Abstract
Exosomes (Exos) are nano-sized extracellular vesicles constitutively released by both prokaryotic and eukaryotic cells. Their role as inter-cellular messengers involved in both physiological and pathological processes has overwhelmingly come to light in the last decade, and their contribution to cancerogenesis and tumor metastasis is under intensive investigation. Here we review the most recent information concerning Exos in colorectal cancer (CRC) and focus on their effects on tumor microenvironment and the immune system, as well as unravel their role in the formation of the pre-metastatic niche and in drug resistance. Such a recent knowledge on Exos depicts their potential translations into the clinical arena, either as an alternative tool of "liquid biopsy" or novel therapeutic approaches for CRC. However, due to the limited data available from clinical trials, they need further validations before addressing their putative application in oncology.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6593071 | PMC |
| http://dx.doi.org/10.3389/fonc.2019.00521 | DOI Listing |
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