Nielsen proposes that a microdynamic approach to experiences occurring in the earliest stages of sleep onset, which he calls microdreams, can shed light on the process of dream imagery formation. I discuss microdreams in the context of simulation views, in which dreaming is defined as the immersive experience of a virtual world centered on a virtual self. I also evaluate his proposal to expand the dimensions included in the oneiragogic spectrum by kinesis. I conclude that while a subset of microdreams might not fulfill the conditions to count as even minimal dreams, their investigation can nonetheless help address key questions in dream research and may even constitute a distinctive pathway to the generation of full-fledged dreaming.
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http://dx.doi.org/10.1093/nc/niz005 | DOI Listing |
ACS Appl Mater Interfaces
September 2024
Bioinspired Microengineering (BIOME) Laboratory, Department of Chemical, Biological and Bio Engineering, North Carolina A&T State University, Greensboro, North Carolina 27265, United States.
The tumor-vascular interface is a critical component of the tumor microenvironment that regulates all of the dynamic interactions between a growing tumor and the endothelial lining of the surrounding vasculature. In this paper, we report the design and development of a custom-engineered tumor-vascular interface system for investigating the early stage tumor-mediated pro-angiogenic dysfunctional behavior of the endothelium. Using representative endothelial cells and triple negative breast cancer cell lines, we established a biomimetic interface between a three-dimensional tumor tissue across a mature, functional endothelial barrier using a magnetically hybrid-integrated tumor-vascular interface system, wherein vasculature-like features containing a monolayer of endothelial cell culture on porous microfluidic channel surfaces were magnetically attached to tumor spheroids generated on a composite polymer-hydrogel microwell plate and embedded in a collagen matrix.
View Article and Find Full Text PDFPLoS One
June 2024
Department of Computer Science, University College London, London, United Kingdom.
This article delves into the dynamics of a dyadic political violence case study in Rojava, Northern Syria, focusing on the conflict between Kurdish rebels and ISIS from January 1, 2017, to December 31, 2019. We employ agent-based modelling and a formalisation of the conflict as an Iterated Prisoner's Dilemma game. The study provides a nuanced understanding of conflict dynamics in a highly volatile region, focusing on microdynamics of an intense dyadic strategic interaction between two near-equally- powered actors.
View Article and Find Full Text PDFActa Pharm Sin B
June 2024
School of Pharmaceutical Sciences, National Key Laboratory of Advanced Drug Delivery System, Medical Science and Technology Innovation Center, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan 250062, China.
The visualization of drugs in living systems has become key techniques in modern therapeutics. Recent advancements in optical imaging technologies and molecular design strategies have revolutionized drug visualization. At the subcellular level, super-resolution microscopy has allowed exploration of the molecular landscape within individual cells and the cellular response to drugs.
View Article and Find Full Text PDFStress Health
October 2024
Department of Psychology, Health, and Technology, University of Twente, Enschede, The Netherlands.
Evidence suggests that complex micro-dynamics occurring in daily life underly the development of mental distress. We aimed to (1) study the cross-lagged association between stressful events and negative affect (NA), (2) show that there is substantial between-person variability in idiographic associations and (3) show that idiographic associations are indicative of mental health. Experience sampling study assessing perceived stressfulness of events (PSE) and NA four times per day for 2 weeks in a non-clinical convenience sample (N = 70, mean age = 22.
View Article and Find Full Text PDFActa Pharm Sin B
April 2024
School of Pharmaceutical Sciences & Institute of Materia Medica, Medical Science and Technology Innovation Center, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan 250062, China.
Small molecule drugs play a pivotal role in the arsenal of anticancer pharmacological agents. Nonetheless, their small size poses a challenge when directly visualizing their localization, distribution, mechanism of action (MOA), and target engagement at the subcellular level in real time. We propose a strategy for developing triple-functioning drug beacons that seamlessly integrate therapeutically relevant bioactivity, precise subcellular localization, and direct visualization capabilities within a single molecular entity.
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