Idiopathic granulomatous mastitis is a rare benign breast disease. A systematic review was designed. Clinical and therapeutic characteristics were analyzed. Human Development Index (HDI) was used to define two groups of study: group A (very high and high HDI) and group B (medium and low HDI). Corticosteroid therapy was done in 69% group A and 78% group B. Surgery was done in 63% in group A and 83% in group B. Antibiotics were used in 68% group A and 88% group B. There is no consensus about optimal treatment for granulomatous mastitis.
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http://dx.doi.org/10.1111/tbj.13446 | DOI Listing |
Cureus
November 2024
Surgery, Arabian Gulf University, Manama, BHR.
Granulomatous mastitis is a chronic inflammation of the breast, mostly of unknown etiology. The treatment would be definitive if the causative organism were isolated. It is characterized histologically by granulomas, formed mostly by polymorph nuclear neutrophils and central necrosis.
View Article and Find Full Text PDFJ Inflamm Res
December 2024
Department of Thyroid and Breast Surgery, The First College of Clinical Medical Science, China Three Gorges University, Yichang, 443022, People's Republic of China.
Purpose: The systemic immune-inflammation index (SII) comprehensively reflects the balance between immune status and host inflammation. We aimed to investigate the potential predictive value of the SII in the prognosis of granulomatous mastitis (GM).
Patients And Methods: We enrolled 245 patients with GM who underwent surgery between 2015 and 2020 in this study.
Breast Care (Basel)
December 2024
General Surgery Department, Şişli Etfal Training and Research Hospital, Istanbul, Turkey.
Objective: Idiopathic granulomatous mastitis (IGM) is a benign inflammatory condition predominantly affecting women of reproductive age, particularly those with a history of breastfeeding. Although the precise etiology remains unknown, treatment strategies continue to be a subject of debate. This study aimed to compare the efficacy of intralesional steroid (ILS) injections with oral steroid (OS) therapy in managing IGM.
View Article and Find Full Text PDFIr J Med Sci
December 2024
Rheumatology Department, Gülhane Training and Research Hospital, University of Health Sciences Turkey, Ankara, Turkey.
Background: Idiopathic granulomatous mastitis (IGM) is a benign and rare chronic inflammatory disease of the breast. Although there are various treatment modalities, an ideal treatment algorithm has not been defined.
Aims: We designed this study to evaluate the clinical status, duration of remission, remission rates, and treatment algorithm in patients with IGM during a 5-year follow-up period after immunosuppressive therapy.
J Breast Imaging
December 2024
Department of Radiology, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.
Cystic neutrophilic granulomatous mastitis (CNGM) is a rare type of granulomatous lobular mastitis (GLM) with a distinct histologic pattern characterized on histopathology by clear lipid vacuoles lined by peripheral neutrophils ("suppurative lipogranulomas"), often containing gram-positive bacilli and strongly associated with Corynebacterial infection (in particular, Corynebacterium kroppenstedtii). Cystic neutrophilic granulomatous mastitis has a distinct histopathologic appearance, but the imaging appearance is less well described and has been limited to case reports and small case series published primarily in pathology literature. Mammographic findings of CNGM include focal asymmetry, skin thickening, and irregular or oval masses.
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