Qualitative vs. Quantitative Methods in Psychiatric Research: Updated.

Since the incipiency of psychiatry as a medical specialty, the "holy grail" has been neuroscience-based diagnostic system and treatment strategies, but this lofty, yet necessary, goal has eluded the greatest minds for centuries. Now, with advances in molecular genetics and resting-state neuroimaging, neuroscience-based diagnosis and treatment are now more possible than ever. However, clinical symptomatology, longitudinal course, and delimitation of illnesses (i.e., phenotypic classification) remain indispensable for responsible, reproducible, and meaningful use of these new methodologies.