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Basic Science and Pathogenesis.
Alzheimers Dement
December 2024
Drexel University college of medicine, Philadelphia, PA, USA.
Background: In tauopathies, such as Frontotemporal Dementia (FTD), tau loses association with microtubules (MTs) and forms neurofibrillary tangles. Tau is an abundant MT-associated protein in neurons, which essentially regulate MT properties. Because pathological tau binds less avidly to MTs, which was thought to reduce the levels and stability of axonal MTs.
View Article and Find Full Text PDFModifying reaction time tasks parameters in the automated IntelliCage identifies heightened impulsivity and impaired attention in the 3xTg-AD model of Alzheimer's disease.
Front Aging Neurosci
December 2024
Arizona State University-Banner Neurodegenerative Disease Research Center at the Biodesign Institute, Arizona State University, Tempe, AZ, United States.
Background: The 3xTg-AD transgenic mouse model of Alzheimer's disease (AD) is an important tool to investigate the relationship between development of pathological amyloid-β (Aβ) and tau, neuroinflammation, and cognitive impairments. Traditional behavioral tasks assessing aspects of learning and memory, such as mazes requiring spatial navigation, unfortunately suffer from several shortcomings, including the stress of human handling and not probing species-typical behavior. The automated IntelliCage system was developed to circumvent such issues by testing mice in a social environment while measuring multiple aspects of cognition.
View Article and Find Full Text PDFTrue Dynamics of Pillararene Host-Guest Binding.
J Chem Theory Comput
December 2024
Changping Laboratory, No. 28 Life Science Park Rd., Beijing 102206, China.
Accurate modeling of host-guest systems is challenging in modern computational chemistry. It requires intermolecular interaction patterns to be correctly described and, more importantly, the dynamic behaviors of macrocyclic hosts to be accurately modeled. Pillar[]arenes as a crucial family of macrocycles play a critical role in host-guest chemistry and biomedical applications.
View Article and Find Full Text PDFC60 fullerene improves the contractile activity of the injured rat muscle gastrocnemius.
Nanotechnology
December 2024
Institute of Chemistry and Biotechnology, Technical University of Ilmenau, Weimarer Str. 25, Ilmenau, 98693, GERMANY.
The powerful antioxidant properties of C60 fullerenes have been widely used in biomedical nanotechnology. Owing to the negative effects of free radicals in oxidative stress processes, antioxidants are required to protect injured muscles. Here, the effect of water-soluble C60 fullerenes (daily oral dose 1 mg/kg) on the process of restoration of contractile activity of skeletal muscle of rats (muscle gastrocnemius) 15 days after the initiation of open trauma of different severity was studied for the first time.
View Article and Find Full Text PDFCorrection: Glycylglycine promotes the solubility and antigenic utility of recombinant HCV structural proteins in a point-of-care immunoassay for detection of active viremia.
Microb Cell Fact
December 2024
Microbial Biotechnology Department, Biotechnology Research Institute, National Research Centre, Dokki, Cairo, 12622, Egypt.
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