Space travelers are exposed to unique forms of ionizing radiation that pose potentially serious health hazards. Prior analyses have attempted to quantify excess mortality risk for astronauts exposed to space radiation, but low statistical power has frustrated inferences. If exposure to deep space radiation were causally linked to deaths due to two particular causes, e.g., cancer and cardiovascular disease, then those cause-specific deaths would not be statistically independent. In this case, a Kaplan-Meier survival curve for a specific cause that treats deaths due to competing causes as uninformative censored events would result in biased estimates of survival probabilities. Here we look for evidence of a deleterious effect of historical exposure to space radiation by assessing whether or not there is evidence for such bias in Kaplan-Meier estimates of survival probabilities for cardiovascular disease and cancer. Evidence of such bias may implicate space radiation as a common causal link to these two disease processes. An absence of such evidence would be evidence that no such common causal link to radiation exposure during space travel exists. We found that survival estimates from the Kaplan-Meier curves were largely congruent with those of competing risk methods, suggesting that if ionizing radiation is impacting the risk of death due to cancer and cardiovascular disease, the effect is not dramatic.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6609703PMC
http://dx.doi.org/10.1038/s41598-019-44858-0DOI Listing

Publication Analysis

Top Keywords

space radiation
20
cardiovascular disease
12
radiation
8
ionizing radiation
8
cancer cardiovascular
8
estimates survival
8
survival probabilities
8
exposure space
8
evidence bias
8
common causal
8

Similar Publications

Holographic multiple-input multiple-output (MIMO) method leverages spatial diversity to enhance the performance of wireless communications and is expected to be a key technology enabling for high-speed data services in the forthcoming sixth generation (6G) networks. However, the antenna array commonly used in the traditional massive MIMO cannot meet the requirements of low cost, low complexity and high spatial resolution simultaneously, especially in higher frequency bands. Hence it is important to achieve a feasible hardware platform to support theoretical study of the holographic MIMO communications.

View Article and Find Full Text PDF

The radium dial painters (RDP) are a well-described group of predominantly young women who incidentally ingested 226Ra and 228Ra as they painted luminescent watch dials in the first part of the twentieth century. In 1974 pathologist Dr. William D.

View Article and Find Full Text PDF

Introduction: Salivary gland malignancies are heterogeneous tumors with highly variable outcomes. Elective neck management options include observation, neck dissection (ND), and neck irradiation (NI). We sought to compare outcomes of cN0 salivary gland cancer by elective neck management.

View Article and Find Full Text PDF

Metal halide perovskite (MHP) solar cells are promising aerospace power sources given their potential as inexpensive, lightweight, and resilient solar electricity generators. Herein, the intrinsic radiation tolerance of unencapsulated methylammonium lead iodide/chloride (CHNHPbICl) films was isolated. Spatially resolved photoluminescence (PL) spectroscopy and confocal microscopy revealed the fundamental defect physics through optical changes as films were irradiated with 4.

View Article and Find Full Text PDF

Purpose: Pulmonary perfusion imaging is a key lung health indicator with clinical utility as a diagnostic and treatment planning tool. However, current nuclear medicine modalities face challenges like low spatial resolution and long acquisition times which limit clinical utility to non-emergency settings and often placing extra financial burden on the patient. This study introduces a novel deep learning approach to predict perfusion imaging from non-contrast inhale and exhale computed tomography scans (IE-CT).

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!