AI Article Synopsis
- The study investigates carotid intima-media thickness (IMT) and related measures as markers of cardiovascular risk in children aged 11-12 and mid-life adults, analyzing the links between parents and their children.
- The research was conducted through a cross-sectional study in various Australian cities, utilizing data from 1,489 children and 1,476 parents with measured carotid IMT.
- Key findings reveal average child IMT measurements of 0.50 mm for mean and 0.58 mm for maximum, with low correlations between mother and child IMT and measures of artery distensibility and elasticity.
Article Abstract
Objectives: To describe a well-established marker of cardiovascular risk, carotid intima-media thickness (IMT) and related measures (artery distensibility and elasticity) in children aged 11-12 years old and mid-life adults, and examine associations within parent-child dyads.
Design: Cross-sectional study (Child Health CheckPoint), nested within a prospective cohort study, the Longitudinal Study of Australian Children (LSAC).
Setting: Assessment centres in seven Australian major cities and eight selected regional towns, February 2015 to March 2016.
Participants: Of all participating CheckPoint families (n=1874), 1489 children (50.0% girls) and 1476 parents (86.8% mothers) with carotid IMT data were included. Survey weights and methods were applied to account for LSAC's complex sample design and clustering within postcodes and strata.
Outcome Measures: Ultrasound of the right carotid artery was performed using standardised protocols. Primary outcomes were mean and maximum far-wall carotid IMT, quantified using semiautomated edge detection software. Secondary outcomes were carotid artery distensibility and elasticity. Pearson's correlation coefficients and multivariable linear regression models were used to assess parent-child concordance. Random effects modelling on a subset of ultrasounds (with repeated measurements) was used to assess reliability of the child carotid IMT measure.
Results: The average mean and maximum child carotid IMT were 0.50 mm (SD 0.06) and 0.58 mm (SD 0.05), respectively. In adults, average mean and maximum carotid IMT were 0.57 mm (SD 0.07) and 0.66 mm (SD 0.10), respectively. Mother-child correlations for mean and maximum carotid IMT were 0.12 (95% CI 0.05 to 0.23) and 0.10 (95% CI 0.03 to 0.21), respectively. For carotid artery distensibility and elasticity, mother-child correlations were 0.19 (95% CI 0.10 to 0.25) and 0.11 (95% CI 0.02 to 0.18), respectively. There was no strong evidence of father-child correlation in any measure.
Conclusions: We provide Australian values for carotid vascular measures and report a modest mother-child concordance. Both genetic and environmental exposures are likely to contribute to carotid IMT.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6624035 | PMC |
| http://dx.doi.org/10.1136/bmjopen-2017-020264 | DOI Listing |
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